Department of Pharmacy, Hunan Cancer Hospital, Changsha, 410013 Hunan, China.
Institute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining, 272000 Shandong, China.
Oxid Med Cell Longev. 2020 Sep 17;2020:9268083. doi: 10.1155/2020/9268083. eCollection 2020.
Accumulating evidence has demonstrated that oxidative stress is associated with depression. Our present study aimed at investigating the antidepressant effect and the possible mechanisms of curcumin (CUR) in chronic unpredictable mild stress- (CUMS-) induced depression model in rats. After exposure to CUMS for four weeks, the rats showed depressive-like behavior, and the depressive-like behaviors in CUMS-treated rats were successfully corrected after administration of CUR. In addition, CUR could effectively decrease protein expression of oxidative stress markers (Nox2, 4-HNE, and MDA) and increase the activity of CAT. CUR treatment also reversed CUMS-induced inhibition of Nrf2-ARE signaling pathway, along with increasing the mRNA expression of NQO-1 and HO-1. Furthermore, the supplementation of CUR also increased the ratio of pCREB/CREB and synaptic-related protein (BDNF, PSD-95, and synaptophysin). In addition, CUR could effectively reverse CUMS-induced reduction of spine density and total dendritic length. In conclusion, the study revealed that CUR relieves depressive-like state through the mitigation of oxidative stress and the activation of Nrf2-ARE signaling pathway.
越来越多的证据表明氧化应激与抑郁症有关。本研究旨在探讨姜黄素（CUR）在慢性不可预测轻度应激（CUMS）诱导的大鼠抑郁模型中的抗抑郁作用及可能机制。在暴露于 CUMS 四周后，大鼠表现出抑郁样行为，而 CUR 给药后可成功纠正 CUMS 处理大鼠的抑郁样行为。此外，CUR 可有效降低氧化应激标志物（Nox2、4-HNE 和 MDA）的蛋白表达，并增加 CAT 活性。CUR 治疗还逆转了 CUMS 诱导的 Nrf2-ARE 信号通路的抑制，同时增加了 NQO-1 和 HO-1 的 mRNA 表达。此外，CUR 的补充还增加了 pCREB/CREB 和突触相关蛋白（BDNF、PSD-95 和突触小体）的比值。此外，CUR 还可有效逆转 CUMS 诱导的棘突密度和总树突长度减少。总之，该研究表明 CUR 通过减轻氧化应激和激活 Nrf2-ARE 信号通路来缓解抑郁样状态。
