Motlagh N S Hosseini, Parvin P, Mirzaie Z H, Karimi R, Sanderson J H, Atyabi F
Department of Biomedical Engineering, Meybod University, PO Box 89616-99557, Meybod, Iran.
Physics Department, Amirkabir University of Technology, PO Box 15875-4413, Tehran, Iran.
Biomed Opt Express. 2020 Jun 16;11(7):3783-3794. doi: 10.1364/BOE.389261. eCollection 2020 Jul 1.
Graphene oxide is used as a singular 2D nano-carrier in cancer therapy. Here, graphene oxide is used as a hybrid chemo-drug graphene oxide (GO) + doxorubicin (DOX), mainly due to its unique chemical and optical properties. The laser triggers GO + DOX for selective drug delivery to optimize the drug release. The characterization of GO is investigated in terms of laser properties at 808 nm. Furthermore, the laser activates GO + DOX compounds to treat MCF7 cancerous cells. The drug release strongly depends on the temperature rise that mainly effects on the viability of the cancerous cells of interest. DOX simultaneously acts as a chemo-drug and as an optical fluorescent agent, whereas GO performs as an efficient photothermal nano-carrier. In fact, the GO-DOX hybrid drug demonstrates multifunctional during malignant cell treatment. We have shown that the laser heating of GO enhances the release percentage up to a treatment yield of 90%. This arises from the synergistic nature of DOX and GO compounds in simultaneous chemo/photo thermal therapy. Furthermore, the fluorescence property of DOX is used to assess the GO uptake using confocal microscope imaging.
氧化石墨烯在癌症治疗中用作单一的二维纳米载体。在此，氧化石墨烯用作混合化疗药物氧化石墨烯（GO）+阿霉素（DOX），主要是由于其独特的化学和光学性质。激光触发GO+DOX进行选择性药物递送，以优化药物释放。在808 nm的激光特性方面对GO进行了表征。此外，激光激活GO+DOX化合物以治疗MCF7癌细胞。药物释放强烈依赖于温度升高，而温度升高主要影响目标癌细胞的活力。DOX同时作为化疗药物和光学荧光剂，而GO作为高效的光热纳米载体。事实上，GO-DOX混合药物在恶性细胞治疗过程中表现出多功能性。我们已经表明，GO的激光加热将释放百分比提高到90%的治疗产率。这源于DOX和GO化合物在同步化疗/光热疗法中的协同性质。此外，DOX的荧光特性用于通过共聚焦显微镜成像评估GO的摄取情况。
