开发一种用于地图样萎缩局部进展的潜在视网膜光学相干断层扫描生物标志物。
Developing a potential retinal OCT biomarker for local growth of geographic atrophy.
作者信息
Yu Yue, Moult Eric M, Chen Siyu, Ren Qiushi, Rosenfeld Philip J, Waheed Nadia K, Fujimoto James G
机构信息
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.
Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Biomed Opt Express. 2020 Aug 20;11(9):5181-5196. doi: 10.1364/BOE.399506. eCollection 2020 Sep 1.
Abstract
Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies.
摘要
地图样萎缩（GA）是年龄相关性黄斑变性的晚期阶段，是导致失明的主要原因。GA病变的特征是各向异性生长，预测生长模式的能力对于评估潜在治疗方法具有重要价值。在本研究中，我们基于OCT在Henle纤维层（HFL）和外核层（ONL）的体积轴向投影，提出了一种基于OCT的局部GA生长率标志物。我们在一小群AMD患者的纵向队列中分析了我们提出的指标与局部GA生长率之间的关联。这些方法有可能用于识别风险标志物、对患者进行分层或在未来的治疗研究中评估反应。
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