HAND2-AS1 在癌症中的作用研究综述。
A review on the role of HAND2-AS1 in cancer.
机构信息
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tehran Lung Research and Developmental Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Clin Exp Med. 2023 Nov;23(7):3179-3188. doi: 10.1007/s10238-023-01092-3. Epub 2023 May 19.
HAND2 antisense RNA 1 (HAND2-AS1) is a newly recognized lncRNA encoded by a gene on 4q34.1. This lncRNA has 10 exons and is predicted to have a positive effect on expression of certain genes. HAND2-AS1 is mainly considered as a tumor suppressive lncRNA in different tissues. Moreover, HAND2-AS1 has been shown to regulate expression of several targets with possible roles in the carcinogenesis through serving as a sponge for miRNAs. This lncRNA can also influence activity of BMP, TGF-β1, JAK/STAT and PI3K/Akt pathways. Down-regulation of HAND2-AS1 in tumor tissues has been associated with larger tumor size, higher tumor grade, higher chance of metastasis and poor clinical outcome. The present study aims at summarization of the impact of HAND2-AS1 in the carcinogenesis and its potential in cancer diagnosis or prediction of cancer prognosis.
HAND2 反义 RNA1（HAND2-AS1）是一种新发现的长链非编码 RNA，由 4q34.1 上的基因编码。该长链非编码 RNA 有 10 个外显子，预计对某些基因的表达有积极影响。HAND2-AS1 在不同组织中主要被认为是一种肿瘤抑制性长链非编码 RNA。此外，HAND2-AS1 已被证明通过作为 microRNA 的海绵来调节几个靶基因的表达，这些靶基因可能在肿瘤发生中发挥作用。这种长链非编码 RNA 还可以影响 BMP、TGF-β1、JAK/STAT 和 PI3K/Akt 通路的活性。肿瘤组织中 HAND2-AS1 的下调与肿瘤体积较大、肿瘤分级较高、转移机会较高和临床预后不良有关。本研究旨在总结 HAND2-AS1 在肿瘤发生中的作用及其在癌症诊断或预测癌症预后中的潜在应用。
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