一种对社区居住老年人主观认知能力下降进行分类的方法。
An approach to classifying subjective cognitive decline in community-dwelling elders.
作者信息
Rabin Laura A, Wang Cuiling, Mogle Jacqueline A, Lipton Richard B, Derby Carol A, Katz Mindy J
机构信息
Department of Psychology Brooklyn College City University of New York (CUNY) Brooklyn New York USA.
Department of Psychology Graduate Center City University of New York (CUNY) New York New York USA.
出版信息
Alzheimers Dement (Amst). 2020 Sep 28;12(1):e12103. doi: 10.1002/dad2.12103. eCollection 2020.
INTRODUCTION
Subjective cognitive decline (SCD) may be an early symptomatic manifestation of Alzheimer's disease, though published research largely neglects how to classify SCD in community-based studies.
METHODS
In neuropsychologically intact Einstein Aging Study participants (n = 1115; mean age = 78; 63% female; 30% non-White), we used Cox models to examine the association between self-perceived cognitive functioning at baseline (using three different approaches) and incident amnestic mild cognitive impairment (aMCI) with covariates of age, sex, education, race/ethnicity, general (objective) cognition, depressive symptoms, and four other SCD-related features.
RESULTS
After a median of 3 years, 198 participants developed aMCI. In models that included all the variables, self-perceived cognitive functioning was consistently associated with incident aMCI as were age, general cognition, and perceived control; apolipoprotein E (APOE) ε4 allele status was significant in one model. We set cut points that optimized the diagnostic accuracy of SCD at various time frames.
DISCUSSION
We provide an approach to SCD classification and discuss implications for cognitive aging studies.
引言
主观认知衰退（SCD）可能是阿尔茨海默病的早期症状表现，尽管已发表的研究在很大程度上忽视了如何在基于社区的研究中对SCD进行分类。
方法
在神经心理学功能完好的爱因斯坦衰老研究参与者（n = 1115；平均年龄 = 78岁；63%为女性；30%为非白人）中，我们使用Cox模型来检验基线时自我感知的认知功能（采用三种不同方法）与遗忘型轻度认知障碍（aMCI）发病之间的关联，并纳入年龄、性别、教育程度、种族/民族、一般（客观）认知、抑郁症状以及其他四个与SCD相关特征作为协变量。
结果
在中位随访3年后，198名参与者出现了aMCI。在包含所有变量的模型中，自我感知的认知功能与aMCI发病始终相关，年龄、一般认知和感知控制也是如此；载脂蛋白E（APOE）ε4等位基因状态在一个模型中具有显著性。我们设定了在不同时间框架内优化SCD诊断准确性的切点。
讨论
我们提供了一种SCD分类方法，并讨论了其对认知衰老研究的意义。
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