Department of Maxillofacial Surgery, Weifang People's Hospital, Weifang, China.
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9423-9428. doi: 10.26355/eurrev_202009_23027.
This study aims to clarify potential diagnostic and prognostic values of KLK11 in nasopharyngeal carcinoma (NPC).
KLK11 levels in 81 primary NPC tissues, 24 recurrent NPC tissues, and 60 nasopharyngeal tissues with chronic mucosal inflammation were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Then, receiver operating characteristic (ROC) curves were depicted for assessing the diagnostic value of KLK11 in primary and recurrent NPC. Next, correlation between KLK11 level and pathological indexes of NPC patients was analyzed by Chi-square test. Enrolled NPC patients were followed up for 5 years, and the follow-up data were recorded to determine the potential influence of KLK11 on overall survival by Kaplan-Meier method. In addition, Cox regression model was applied for assessing factors that could affect prognosis of NPC patients.
It was found that KLK11 level was higher in primary NPC tissues than that in nasopharyngeal tissues with chronic mucosal inflammation. In recurrent NPC tissues, KLK11 was upregulated relative to primary ones. In addition, ROC curves revealed a certain diagnostic value of KLK11 in NPC. Overall survival was worse in primary and recurrent NPC patients expressing a high level of KLK11. By analyzing the pathological indexes of NPC patients, KLK11 level was found to be correlated with age, T stage, and clinical stage of NPC patients. Furthermore, KLK11 level was found to be the risk factor influencing the survival of NPC patients.
KLK11 is upregulated in NPC tissues, and unfavorable to the prognosis of NPC. Besides, it can be utilized as a potential hallmark for diagnosing NPC.
本研究旨在阐明 KLK11 在鼻咽癌（NPC）中的潜在诊断和预后价值。
通过实时定量聚合酶链反应（qRT-PCR）检测 81 例原发性 NPC 组织、24 例复发性 NPC 组织和 60 例慢性黏膜炎症鼻咽组织中的 KLK11 水平。然后，通过绘制受试者工作特征（ROC）曲线来评估 KLK11 在原发性和复发性 NPC 中的诊断价值。接下来，通过卡方检验分析 KLK11 水平与 NPC 患者病理指标的相关性。对入组的 NPC 患者进行 5 年随访，并记录随访数据，通过 Kaplan-Meier 法确定 KLK11 对总生存的潜在影响。此外，应用 Cox 回归模型评估影响 NPC 患者预后的因素。
研究发现，KLK11 在原发性 NPC 组织中的表达高于慢性黏膜炎症的鼻咽组织，在复发性 NPC 组织中相对原发性 NPC 组织上调。此外，ROC 曲线显示 KLK11 在 NPC 中具有一定的诊断价值。高表达 KLK11 的原发性和复发性 NPC 患者的总生存率较差。通过分析 NPC 患者的病理指标，发现 KLK11 水平与 NPC 患者的年龄、T 分期和临床分期相关。此外，KLK11 水平被发现是影响 NPC 患者生存的危险因素。
KLK11 在 NPC 组织中上调，不利于 NPC 的预后。此外，它可以作为诊断 NPC 的潜在标志物。
