Atik Hülya, Bülbül Tuba, Özdemir Vural, Avci Gülcan, Bülbül Aziz
Department of Physiology, Faculty of Veterinary Medicine, University of Afyon Kocatepe, Afyonkarahisar, Turkey.
Department of Animal Nutrition and Nutritional Diseases, Faculty of Milas Veterinary Medicine, University of Mugla Sıtkı Kocman, Mugla, Turkey.
J Food Biochem. 2020 Dec;44(12):e13498. doi: 10.1111/jfbc.13498. Epub 2020 Oct 4.
Among today's health problems, metabolic diseases are at the forefront. Hypothyroidism (HT) is a disease characterized by increased TSH, decreased T3&T4 concentrations in serum, with overall metabolic slowdown. Although there are many studies in the literature about oxidative status in HT, statements in these studies are contradictory. In our study, the effect of essential oils obtained from the leaves, flowers, and roots of Myrtus communis L. on oxidative metabolism in an HT model induced by propylthiouracil (PTU) in rats was investigated. A total of 36 Wistar albino rats were randomly divided into six groups as follows: (1) Control, (2) PTU, (3) M. communis L. oil 200 (MO 200), (4) M. communis L. oil 400 (MO 400), (5) PTU + MO 200, and (6) PTU + MO 400. In our study, while oxidative status deteriorates in groups given PTU, antioxidant activity increases in groups given M. communis L. oil. PRACTICAL APPLICATIONS: Essential oils are aromatic oily liquids derived from different parts of plants. M. communis L. is one of the best-known herbs in the class of aromatic and medicinal plants. This paper emphasizes the effect of M. communis L. oil on the negative oxidative state that occurs in HT conditions. The present study provides a positive effect of essential oils obtained from the M. communis L. on the oxidative state seen in HT. In light of this information, it may be beneficial to use M. communis L. oil due to its antioxidative effect in HT conditions.
在当今的健康问题中，代谢性疾病处于前沿位置。甲状腺功能减退症（HT）是一种以促甲状腺激素（TSH）升高、血清中三碘甲状腺原氨酸（T3）和甲状腺素（T4）浓度降低以及整体代谢减缓为特征的疾病。尽管文献中有许多关于HT氧化状态的研究，但这些研究中的说法相互矛盾。在我们的研究中，调查了从香桃木的叶、花和根中提取的精油对丙硫氧嘧啶（PTU）诱导的大鼠HT模型中氧化代谢的影响。总共36只Wistar白化大鼠被随机分为以下六组：（1）对照组，（2）PTU组，（3）香桃木油200组（MO 200），（4）香桃木油400组（MO 400），（5）PTU + MO 200组，以及（6）PTU + MO 400组。在我们的研究中，给予PTU的组氧化状态恶化，而给予香桃木油的组抗氧化活性增加。实际应用：精油是从植物不同部位提取的芳香油性液体。香桃木是芳香和药用植物类别中最著名的草药之一。本文强调了香桃木油对HT条件下出现的负氧化状态的影响。本研究表明，从香桃木中提取的精油对HT中所见的氧化状态具有积极作用。鉴于此信息，由于其在HT条件下的抗氧化作用，使用香桃木油可能有益。
