Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, P.R. China.
Nat Prod Res. 2022 May;36(9):2270-2276. doi: 10.1080/14786419.2020.1828406. Epub 2020 Oct 4.
A new dimeric monoterpene indole alkaloid polonidine A (), along with five known compounds, cyclopenol (), verrucosidin (), fructigenine A (), 3-O-methylviridicatin () and aurantiomides C (), were isolated from TY12. Their structures were established on the basis of extensive spectroscopic analyses. Compound exhibited moderate cytotoxic activities and moderate antibacterial activity against with MIC of 4.0 μg/mL.
从 TY12 中分离得到了一种新的二聚单萜吲哚生物碱波罗宁 A ()，以及另外五种已知化合物：环丙醇 ()、疣孢菌素 ()、果糖基福司汀 A ()、3-O-甲基育亨宾 () 和橙皮酰胺 C ()。基于广泛的光谱分析确定了它们的结构。化合物 表现出中等的细胞毒性和对 的中等抗菌活性，MIC 为 4.0 μg/mL。
