Department of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstr. 4, 85747 Garching b. München, Germany.
Department of Chemistry and Catalysis Research Center, Chair of Organic Chemistry I, Technische Universität München, Lichtenbergstr. 4, 85747 Garching b. München, Germany.
Dalton Trans. 2020 Oct 20;49(40):14106-14114. doi: 10.1039/d0dt02598d.
Two sets of macrocyclic, bio-inspired, non-heme ligands are utilized for the synthesis of NiII, PdII and PtII complexes. The ligands consist of a 16-atom macrocycle, formed by four methylene bridged NHC moieties, with imidazole or benzimidazole as building blocks. The complexes exhibit a square planar coordination geometry and are characterized by NMR, ESI-MS, elemental analysis, SC-XRD and UV/Vis. For complexes incorporating benzimidazole, an evaluation of luminescence properties is performed, and is found that phosphorescence is present for the PdII derivative and there is fluorescence for the PtII derivative. Stability studies in cell culture medium are performed for subsequent MTT assays. Here, the NiII complexes show low to no activity, and PdII and PtII complexes exhibit remarkable low IC50 values in cisplatin resistant A2780cisR cells.
利用两组大环、生物启发的非血红素配体合成了 NiII、PdII 和 PtII 配合物。配体由四个亚甲基桥连的 NHC 部分组成的 16 原子大环组成，以咪唑或苯并咪唑为构建块。配合物具有正方形平面配位几何形状，并通过 NMR、ESI-MS、元素分析、SC-XRD 和 UV/Vis 进行了表征。对于包含苯并咪唑的配合物，进行了发光性质的评估，发现 PdII 衍生物存在磷光，而 PtII 衍生物存在荧光。在细胞培养基中进行稳定性研究，以进行随后的 MTT 测定。在这里，NiII 配合物显示出低至无活性，而 PdII 和 PtII 配合物在顺铂耐药 A2780cisR 细胞中表现出显著的低 IC50 值。
