Veréb Dániel, Tóth Eszter, Bozsik Bence, Király András, Szabó Nikoletta, Kincses Bálint, Kocsis Krisztián, Faragó Péter, László Vécsei, Bencsik Krisztina, Klivényi Péter, Kincses Zsigmond Tamás
Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary/Neuroimaging Research Group, Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
Mult Scler. 2021 Aug;27(9):1341-1349. doi: 10.1177/1352458520958360. Epub 2020 Oct 5.
Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce.
To investigate connectivity within and between task-related networks in multiple sclerosis during a visual attention task as a function of cognitive performance.
A total of 23 relapsing-remitting multiple sclerosis (RRMS) patients and 29 healthy controls underwent task-functional magnetic resonance imaging (fMRI) scans using a visual attention paradigm on a 3T scanner. Scans were analysed using tensor-independent component analysis (TICA). Functional connectivity was calculated within and between components. We assessed cognitive function with the Brief International Cognitive Assessment for MS (BICAMS) battery.
TICA extracted components related to visual processing, attention, executive function and the default-mode network. Subject scores of visual/attention-related and executive components were greater in healthy controls ( < 0.032, < 0.023). Connectivity between visual/attention-related and default-mode components was higher in patients ( < 0.043), correlating with Brief Visuospatial Memory Test-Revised (BVMT-R) scores ( = -0.48, < 0.036). Patients showed reduced connectivity between the right intraparietal sulcus (rIPS) and frontal eye field (rFEF), and bilateral frontal eye fields ( < 0.012, < 0.003). Reduced rIPS-rFEF connectivity came with lower Symbol Digit Modalities Test (SDMT)/BVMT-R scores in patients ( = 0.53, < 0.02, = 0.46, < 0.049).
Attention-related networks show altered connectivity during task performance in RRMS patients, scaling with cognitive disability.
多发性硬化可能会损害包括注意力在内的多个认知领域的表现。尽管在静息状态下已描述了注意力网络缺陷，但研究任务执行过程中其功能的研究却很少。
研究多发性硬化患者在视觉注意力任务期间与任务相关网络内部及之间的连通性，作为认知表现的函数。
总共23例复发缓解型多发性硬化（RRMS）患者和29名健康对照者在3T扫描仪上使用视觉注意力范式进行了任务功能磁共振成像（fMRI）扫描。使用张量独立成分分析（TICA）对扫描进行分析。计算成分内部及之间的功能连通性。我们使用多发性硬化症简易国际认知评估（BICAMS）量表评估认知功能。
TICA提取了与视觉处理、注意力、执行功能和默认模式网络相关的成分。健康对照者的视觉/注意力相关成分和执行成分的受试者分数更高（<0.032，<0.023）。患者的视觉/注意力相关成分与默认模式成分之间的连通性更高（<0.043），与简易视觉空间记忆测试修订版（BVMT-R）分数相关（=-0.48，<0.036）。患者右侧顶内沟（rIPS）与额眼区（rFEF）以及双侧额眼区之间的连通性降低（<0.012，<0.003）。患者rIPS-rFEF连通性降低伴随着较低的符号数字模式测试（SDMT）/BVMT-R分数（=0.53，<0.02，=0.46，<0.049）。
RRMS患者在任务执行期间，与注意力相关的网络显示出连通性改变，并与认知障碍程度相关。
