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血清尿酸和高敏 C 反应蛋白可预测脑梗死患者的认知障碍。

Serum Uric Acid and High-Sensitivity C-Reactive Protein as Predictors of Cognitive Impairment in Patients with Cerebral Infarction.

机构信息

Division 2 of Neurology, Cangzhou People's Hospital, Cangzhou, China.

Department of Anorectal Surgery, Medical College District of Cangzhou People's Hospital, Cangzhou, China.

出版信息

Dement Geriatr Cogn Disord. 2020;49(3):235-242. doi: 10.1159/000507806. Epub 2020 Oct 5.

DOI:10.1159/000507806
PMID:33017823
Abstract

BACKGROUND

Cognitive impairment induced by cerebral infarction has become a devastating health problem. More efficient predictors are required to evaluate the potential cognitive decline after cerebral infarction in clinic. Serum uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) are two factors reported to correlate with cognitive impairment. However, the understanding on serum UA and hs-CRP with cognitive dysfunction remains unclear.

METHODS

Serum UA and hs-CRP were evaluated in patients with cerebral infarction (n = 197) using single factor analysis and multivariate logistic regression analysis. Clinical and pathological characteristics were analyzed by logistic regression, respectively, and the results demonstrated the correlation between the pathological characteristics and the cognitive impairment post cerebral infarction. Montreal Cognitive Assessment (MoCA) was used to evaluate the patients' cognitive function, and patients with a MoCA score <26 were recognized as with cognitive impairment.

RESULTS

Clinical characteristics related to cognitive impairment, including age, gender, blood pressure, serum UA, and hs-CRP were collected and analyzed. Serum UA and hs-CRP were identified to be potential predictors for post-stroke cognitive dysfunction, with higher serum UA levels correlated with better cognitive function and higher hs-CRP levels correlated with worse cognitive impairment.

CONCLUSION

Serum UA and hs-CRP are two predictors for cognitive impairment post cerebral infarction.

摘要

背景

脑梗死引起的认知障碍已成为严重的健康问题。需要更有效的预测指标来评估脑梗死患者的潜在认知能力下降。血清尿酸（UA）和高敏 C 反应蛋白（hs-CRP）是与认知障碍相关的两个因素。然而，对于血清 UA 和 hs-CRP 与认知功能障碍的关系，目前尚不清楚。

方法

采用单因素分析和多因素 logistic 回归分析检测 197 例脑梗死患者的血清 UA 和 hs-CRP。通过 logistic 回归分析临床和病理特征，结果表明病理特征与脑梗死后认知障碍之间存在相关性。采用蒙特利尔认知评估量表（MoCA）评估患者的认知功能，MoCA 评分<26 分的患者被认为存在认知障碍。

结果

收集和分析了与认知障碍相关的临床特征，包括年龄、性别、血压、血清 UA 和 hs-CRP。血清 UA 和 hs-CRP 被确定为卒中后认知功能障碍的潜在预测因子，较高的血清 UA 水平与较好的认知功能相关，而较高的 hs-CRP 水平与较差的认知障碍相关。

结论

血清 UA 和 hs-CRP 是脑梗死后认知障碍的两个预测因子。

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