光介导超声疗法治疗视网膜新生血管
Photo-mediated Ultrasound Therapy to Treat Retinal Neovascularization.
作者信息
Paulus Yannis M, Qin Yu, Yu Yixin, Fu Julia, Wang Xueding, Yang Xinmai
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:5244-5247. doi: 10.1109/EMBC44109.2020.9175882.
Abstract
This report describes a novel therapeutic technique called photo-mediated ultrasound therapy (PUT). PUT applies synchronized short pulse duration (nanosecond) laser and ultrasound burst on targeted tissue, offering high-precision localized treatment. PUT is based on controlled induction and promotion of micro-cavitation activity in the target tissue. PUT is able to safely and effectively treat retinal neovascularization in rabbits with persistent nonperfusion up to 4 weeks after PUT in the choroidal vasculature.Clinical Relevance- PUT can selectively remove retinal angiogenesis in clinically-relevant disease models in humansized eyes (rabbit) without damaging surrounding tissue.
摘要
本报告描述了一种名为光介导超声疗法（PUT）的新型治疗技术。PUT将同步的短脉冲持续时间（纳秒）激光和超声脉冲应用于目标组织，提供高精度的局部治疗。PUT基于对目标组织中微空化活性的可控诱导和促进。PUT能够安全有效地治疗脉络膜血管系统中PUT后持续无灌注达4周的兔视网膜新生血管。临床意义——PUT可以在人眼大小（兔）的临床相关疾病模型中选择性地消除视网膜血管生成，而不损伤周围组织。
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