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关于影响糖尿病管理的行为因素的数据驱动见解。

Data-Driven Insights on Behavioral Factors that Affect Diabetes Management.

作者信息

Morton Samuel, Li Rui, Dibbo Sayanton, Prioleau Temiloluwa

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:5557-5562. doi: 10.1109/EMBC44109.2020.9176414.

DOI:10.1109/EMBC44109.2020.9176414
PMID:33019237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11373456/
Abstract

The prevalence of personal health data from wearable devices enables new opportunities to understand the impact of behavioral factors on health. Unlike consumer devices that are often auxiliary, such as Fitbit and Garmin, wearable medical devices like continuous glucose monitoring (CGM) devices and insulin pumps are becoming critical in diabetes care to minimize the occurrence of adverse glycemic events. Joint analysis of CGM and insulin pump data can provide unparalleled insights on how to modify treatment regimen to improve diabetes management outcomes. In this paper, we employ a data-driven approach to study the relationship between key behavioral factors and proximal diabetic management indicators. Our dataset includes an average of 161 days of time-matched CGM and insulin pump data from 34 subjects with Type 1 Diabetes (T1D). By employing hypothesis testing and association mining, we observe that smaller meals and insulin doses are associated with better glycemic outcomes compared to larger meals and insulin doses. Meanwhile, the occurrence of interrupted sleep is associated with poorer glycemic outcomes. This paper introduces a method for inferring disrupted sleep from wearable diabetes-device data and provides a baseline for future research on sleep quality and diabetes. This work also provides insights for development of decision-support tools for improving short- and long-term outcomes in diabetes care.

摘要

可穿戴设备产生的个人健康数据的普及为了解行为因素对健康的影响带来了新机遇。与通常作为辅助设备的消费级设备(如Fitbit和佳明)不同,连续血糖监测(CGM)设备和胰岛素泵等可穿戴医疗设备在糖尿病护理中变得至关重要,以尽量减少不良血糖事件的发生。对CGM和胰岛素泵数据进行联合分析可以为如何调整治疗方案以改善糖尿病管理结果提供无与伦比的见解。在本文中,我们采用数据驱动的方法来研究关键行为因素与近端糖尿病管理指标之间的关系。我们的数据集包括来自34名1型糖尿病(T1D)患者的平均161天时间匹配的CGM和胰岛素泵数据。通过进行假设检验和关联挖掘,我们观察到与较大的餐食和胰岛素剂量相比,较小的餐食和胰岛素剂量与更好的血糖结果相关。同时,睡眠中断的发生与较差的血糖结果相关。本文介绍了一种从可穿戴糖尿病设备数据中推断睡眠中断的方法,并为未来关于睡眠质量和糖尿病的研究提供了基线。这项工作还为开发决策支持工具以改善糖尿病护理的短期和长期结果提供了见解。

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本文引用的文献

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Automated meal detection from continuous glucose monitor data through simulation and explanation.通过模拟和解释实现连续血糖监测数据的自动膳食检测。
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Amount and Type of Dietary Fat, Postprandial Glycemia, and Insulin Requirements in Type 1 Diabetes: A Randomized Within-Subject Trial.1 型糖尿病患者的膳食脂肪量和类型、餐后血糖和胰岛素需求:一项随机自身对照试验。
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Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range.临床连续血糖监测数据解读目标:时间范围国际共识推荐意见。
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Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report.成人糖尿病或糖尿病前期的营养治疗:共识报告。
Diabetes Care. 2019 May;42(5):731-754. doi: 10.2337/dci19-0014. Epub 2019 Apr 18.
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Prediction of Adverse Glycemic Events From Continuous Glucose Monitoring Signal.基于连续血糖监测信号预测不良血糖事件。
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Sleep in Type 1 Diabetes: Implications for Glycemic Control and Diabetes Management.1 型糖尿病患者的睡眠:对血糖控制和糖尿病管理的影响。
Curr Diab Rep. 2018 Feb 5;18(2):5. doi: 10.1007/s11892-018-0974-8.
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International Consensus on Use of Continuous Glucose Monitoring.连续血糖监测应用的国际共识
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Sleep characteristics in type 1 diabetes and associations with glycemic control: systematic review and meta-analysis.1型糖尿病的睡眠特征及其与血糖控制的关联:系统评价与荟萃分析
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