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神经生理模型:一种用于血糖预测的简单模块。

Neural Physiological Model: A Simple Module for Blood Glucose Prediction.

作者信息

Gu Kang, Dang Ruoqi, Prioleau Temiloluwa

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:5476-5481. doi: 10.1109/EMBC44109.2020.9176004.

DOI:10.1109/EMBC44109.2020.9176004
PMID:33019219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11373455/
Abstract

Continuous glucose monitors (CGM) and insulin pumps are becoming increasingly important in diabetes management. Additionally, data streams from these devices enable the prospect of accurate blood glucose prediction to support patients in preventing adverse glycemic events. In this paper, we present Neural Physiological Encoder (NPE), a simple module that leverages decomposed convolutional filters to automatically generate effective features that can be used with a downstream neural network for blood glucose prediction. To our knowledge, this is the first work to investigate a decomposed architecture in the diabetes domain. Our experimental results show that the proposed NPE model can effectively capture temporal patterns and blood glucose associations with other daily activities. For predicting blood glucose 30-mins in advance, NPE+LSTM yields an average root mean square error (RMSE) of 9.18 mg/dL on an in-house diabetes dataset from 34 subjects. Additionally, it achieves state-of-the-art RMSE of 17.80 mg/dL on a publicly available diabetes dataset (OhioT1DM) from 6 subjects.

摘要

连续血糖监测仪(CGM)和胰岛素泵在糖尿病管理中变得越来越重要。此外,这些设备的数据流使准确预测血糖成为可能,从而帮助患者预防不良血糖事件。在本文中,我们提出了神经生理编码器(NPE),这是一个简单的模块,它利用分解的卷积滤波器自动生成有效的特征,这些特征可与下游神经网络一起用于血糖预测。据我们所知,这是第一项在糖尿病领域研究分解架构的工作。我们的实验结果表明,所提出的NPE模型可以有效地捕捉时间模式以及血糖与其他日常活动的关联。对于提前30分钟预测血糖,在来自34名受试者的内部糖尿病数据集上,NPE + LSTM的平均均方根误差(RMSE)为9.18 mg/dL。此外,在来自6名受试者的公开可用糖尿病数据集(OhioT1DM)上,它实现了17.80 mg/dL的最新RMSE。

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本文引用的文献

1
Predicting Glycaemia in Type 1 Diabetes Patients: Experiments in Feature Engineering and Data Imputation.预测1型糖尿病患者的血糖水平:特征工程与数据插补实验
J Healthc Inform Res. 2019 Dec 10;4(1):71-90. doi: 10.1007/s41666-019-00063-2. eCollection 2020 Mar.
2
The OhioT1DM Dataset for Blood Glucose Level Prediction: Update 2020.用于血糖水平预测的俄亥俄州1型糖尿病数据集:2020年更新
CEUR Workshop Proc. 2020 Sep;2675:71-74.
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Data-Driven Insights on Behavioral Factors that Affect Diabetes Management.关于影响糖尿病管理的行为因素的数据驱动见解。
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:5557-5562. doi: 10.1109/EMBC44109.2020.9176414.
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Leveraging a Big Dataset to Develop a Recurrent Neural Network to Predict Adverse Glycemic Events in Type 1 Diabetes.利用大数据集开发循环神经网络以预测1型糖尿病患者的不良血糖事件。
IEEE J Biomed Health Inform. 2019 Apr 17. doi: 10.1109/JBHI.2019.2911701.
5
Convolutional Recurrent Neural Networks for Glucose Prediction.卷积循环神经网络在血糖预测中的应用。
IEEE J Biomed Health Inform. 2020 Feb;24(2):603-613. doi: 10.1109/JBHI.2019.2908488. Epub 2019 Apr 1.
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Current Diabetes Technology: Striving for the Artificial Pancreas.当前糖尿病技术:迈向人工胰腺的征程
Diagnostics (Basel). 2019 Mar 15;9(1):31. doi: 10.3390/diagnostics9010031.
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Artificial Intelligence for Diabetes Management and Decision Support: Literature Review.用于糖尿病管理和决策支持的人工智能:文献综述
J Med Internet Res. 2018 May 30;20(5):e10775. doi: 10.2196/10775.
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International Consensus on Use of Continuous Glucose Monitoring.连续血糖监测应用的国际共识
Diabetes Care. 2017 Dec;40(12):1631-1640. doi: 10.2337/dc17-1600.
9
Glucose Sensing for Diabetes Monitoring: Recent Developments.用于糖尿病监测的葡萄糖传感:最新进展。
Sensors (Basel). 2017 Aug 12;17(8):1866. doi: 10.3390/s17081866.
10
Comment on American Diabetes Association. . Diabetes Care 2017;40(Suppl. 1):S1-S135.对美国糖尿病协会的评论。《糖尿病护理》2017年;40(增刊1):S1 - S135。
Diabetes Care. 2017 Jul;40(7):e92-e93. doi: 10.2337/dc17-0299.