Zhu Xiaolei, Zhang Xiaochang, Hu Xiao, Ren Hongyan, Wu Shenghui, Wu Jing, Wu Guoyi, Si Xiang, Wang Baohua
Office of Noncommunicable Disease Control and Aging Health, Chinese Center for Disease Control and Prevention.
Information Center, Beijing Center for Disease Control and Prevention, Beijing, China.
Medicine (Baltimore). 2020 Oct 2;99(40):e22292. doi: 10.1097/MD.0000000000022292.
This study aims to assess the survival status of patients with Primary gallbladder cancer (PGC) and analyze the prognosis factors to facilitate the exploration of the prevention and therapeutic strategies of PGC.Data from 2433 PGC patients collected from 2010 to 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The SEER*Stat, SPSS 23.0 and GraphPad Prism 8 were used for statistical analyses. Kaplan Meier analysis was performed for the survival curve, log-rank test analyses were used to compare the survival rate difference and Cox regression analyses were performed to determine the prognosis factors.A total of 2433 PGC cases were reported from 2010 to 2015. The median age was 64.2 ± 10.4 years old and the percentages of the white patients were 73.7% (1794/2433). The percentage of patients who received surgery treatment was 82.1% (1998/2433). The overall median survival time of all patients was 19 months and the 5-year survival rate was 28.8%. The 5-year survival rate of PGC patients in pN2 stage dropped to 0% and the 5-year survival rate for PGC patients with distant metastasis was only 2.7%. Age, tumor size, grade, pT stage, pM stage were risk factors for prognosis, surgery or not and radiation or not were protective factors for prognosis.Survival analysis of PGC patients based on the SEER database have provided an opportunity for understanding PGC prognosis and the basis for the exploration of viable PGC prevention and therapeutic strategies.
本研究旨在评估原发性胆囊癌（PGC）患者的生存状况，并分析预后因素，以促进对PGC预防和治疗策略的探索。从监测、流行病学和最终结果（SEER）数据库中提取了2010年至2015年收集的2433例PGC患者的数据。使用SEER*Stat、SPSS 23.0和GraphPad Prism 8进行统计分析。对生存曲线进行Kaplan Meier分析，使用对数秩检验分析比较生存率差异，并进行Cox回归分析以确定预后因素。
2010年至2015年共报告了2433例PGC病例。中位年龄为64.2±10.4岁，白人患者占73.7%（1794/2433）。接受手术治疗的患者比例为82.1%（1998/2433）。所有患者的总体中位生存时间为19个月，5年生存率为28.8%。pN2期PGC患者的5年生存率降至0%，远处转移的PGC患者5年生存率仅为2.7%。年龄、肿瘤大小、分级、pT分期、pM分期是预后的危险因素，是否手术和是否放疗是预后的保护因素。
基于SEER数据库对PGC患者的生存分析为了解PGC预后提供了机会，并为探索可行的PGC预防和治疗策略奠定了基础。
