Division of Host-Microbe Systems & Therapeutics, Center for Immunity, Infection & Inflammation, Collaborative to Halt Antimicrobial Resistant Microbes, University of California-San Diego School of Medicine, La Jolla, California, USA
Antimicrob Agents Chemother. 2020 Dec 16;65(1). doi: 10.1128/AAC.02039-20.
Given that it is unlikely that randomized clinical trials will yield answers for treating the most challenging bacteremic infections caused by methicillin-resistant , clinicians, microbiologists, and pharmacists will have to cooperate to discover novel ways to select successful individualized antimicrobial therapy for these patients. An example of such a strategy was demonstrated in the identification and utilization of imipenem/cilastatin plus fosfomycin to treat a particularly recalcitrant MRSA bacteremia and spinal abscess.
鉴于不太可能通过随机临床试验来找到治疗最具挑战性的耐甲氧西林金黄色葡萄球菌引起的菌血症感染的方法，临床医生、微生物学家和药剂师将不得不合作，为这些患者发现成功的个体化抗菌治疗的新方法。这种策略的一个例子是在鉴定和使用亚胺培南/西司他丁加磷霉素来治疗一种特别难治的耐甲氧西林金黄色葡萄球菌菌血症和脊髓脓肿时得到了证明。
