埃及鸡源大肠埃希氏菌中同时高产 Tet(X7)、高水平替加环素耐药、磷霉素 fosA4 和多粘菌素 Mcr-1.1
Coproduction of Tet(X7) Conferring High-Level Tigecycline Resistance, Fosfomycin FosA4, and Colistin Mcr-1.1 in Escherichia coli Strains from Chickens in Egypt.
机构信息
Laboratory of Food Microbiology and Hygiene, Graduate School of Biosphere Science, Hiroshima University, Higashihiroshima, Japan
Department of Microbiology and Immunology, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh, Egypt.
出版信息
Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.02084-20.
Abstract
The plasmid-mediated (X7) conferring high-level tigecycline resistance was identified in five -positive strains (ST10 [ = 3] and ST155 [ = 2]) isolated from chickens in Egypt. Two fosfomycin-resistant -carrying IncFII plasmids (∼79 kb in size) were detected. Transposase IS (IS family) is syntenic with (X7) in all isolates, suggesting its role in the mobilization of (X7). To our knowledge, this is the first global report of ST4-IncHI2 plasmids cocarrying (X7) and from chickens.
摘要
在从埃及鸡中分离的 5 株阳性菌株（ST10 [=3] 和 ST155 [=2]）中发现了质粒介导的（X7），可导致高水平替加环素耐药。检测到两种含有磷霉素抗性的 IncFII 质粒（大小约为 79kb）。转座酶 IS（IS 家族）与所有分离株中的（X7）共线性，表明其在（X7）的动员中起作用。据我们所知，这是首次在鸡中报告 ST4-IncHI2 质粒共携带（X7）和 的全球情况。
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