Zhang Guoming, Yang Mingmin, Wu Zhenquan, Lam Waiching, Lian Chaohui, Zhao Guanglin, Zeng Jian, Qiu Yuxing, Li Na, Zhuang Runsen
Pediatric Retinal Surgery Department, Shenzhen Eye Hospital, Shenzhen Key Ophthalmic Laboratory, the Second Affiliated Hospital of JiNan University, Shenzhen, China.
Department of Ophthalmology, The University of Hong Kong, Grantham Hospital, Hong Kong, China.
Ophthalmic Epidemiol. 2021 Aug;28(4):359-364. doi: 10.1080/09286586.2020.1826542. Epub 2020 Oct 6.
To report the changes in incidence and risk factors of retinopathy of prematurity (ROP) in extremely low birth weight (ELBW) infants over a 15-year period in South China.
The medical records of ELBW infants were retrospectively reviewed through established database of Shenzhen Screening for ROP Cooperative Group. The incidence and severity of ROP were compared among three successive 5-year periods (P1: 2004-2008, P2: 2009-2013, P3: 2014-2018). Gestational age, birth weight, plurality, mode of delivery and gender were analyzed as risk factors for ROP in ELBW infants.
Among the 1099 included ELBW infants, 557 (50.7%) had ROP, and 328 (29.9%) had severe ROP. The highest incidence of ROP (87.5%) and severe ROP (82.5%) were seen in P1. From P2 to P3, the incidence of ROP and severe ROP increased from 45.9% to 50.3% for ROP ( < .05) and from 26.4% to 28.3% for severe ROP ( < .05), respectively. Multivariate logistic regression analysis found only gestational age has a significant effect on the incidence of ROP and severe ROP.
From 2004 to 2018, the incidence of ROP and severe ROP in ELBW infants in South China was 50.7% and 29.9%, respectively. Controlling for the other risk factors, only gestational age was statistically associated with ROP in ELBW infants.
报告中国南方极低出生体重（ELBW）婴儿15年间早产儿视网膜病变（ROP）的发病率变化及危险因素。
通过深圳ROP筛查协作组的既定数据库对ELBW婴儿的病历进行回顾性分析。比较三个连续5年期间（P1：2004 - 2008年，P2：2009 - 2013年，P3：2014 - 2018年）ROP的发病率和严重程度。分析胎龄、出生体重、多胎情况、分娩方式和性别作为ELBW婴儿ROP的危险因素。
在纳入的1099例ELBW婴儿中，557例（50.7%）患有ROP，328例（29.9%）患有重度ROP。ROP（87.5%）和重度ROP（82.5%）的最高发病率出现在P1期。从P2到P3，ROP和重度ROP的发病率分别从45.9%升至50.3%（P<0.05）和从26.4%升至28.3%（P<0.05）。多因素logistic回归分析发现只有胎龄对ROP和重度ROP的发病率有显著影响。
2004年至2018年，中国南方ELBW婴儿中ROP和重度ROP的发病率分别为50.7%和29.9%。在控制其他危险因素的情况下，只有胎龄与ELBW婴儿的ROP存在统计学关联。
