Department of Basic and Oral Biology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-904, Brazil.
Department of Basic and Oral Biology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-904, Brazil.
Eur J Pharmacol. 2020 Dec 15;889:173629. doi: 10.1016/j.ejphar.2020.173629. Epub 2020 Oct 3.
The absence of a specific treatment for SARS-CoV-2 infection led to an intense global effort in order to find new therapeutic interventions and improve patient outcomes. One important feature of COVID-19 pathophysiology is the activation of immune cells, with consequent massive production and release of inflammatory mediators that may cause impairment of several organ functions, including the brain. In addition to its classical role as a neurotransmitter, serotonin (5-hydroxytryptamine, 5-HT) has immunomodulatory properties, downregulating the inflammatory response by central and peripheral mechanisms. In this review, we describe the roles of 5-HT in the regulation of systemic inflammation and the potential benefits of the use of specific serotonin reuptake inhibitors as a coadjutant therapy to attenuate neurological complications of COVID-19.
由于缺乏针对 SARS-CoV-2 感染的特定治疗方法，全球范围内开展了大量研究工作，旨在寻找新的治疗干预措施并改善患者的预后。COVID-19 病理生理学的一个重要特征是免疫细胞的激活，随之而来的是大量炎症介质的产生和释放，这可能导致包括大脑在内的多个器官功能受损。除了作为经典的神经递质外，5-羟色胺（5-羟色胺，5-HT）还具有免疫调节特性，通过中枢和外周机制下调炎症反应。在这篇综述中，我们描述了 5-HT 在调节全身炎症中的作用，以及使用特定的 5-羟色胺再摄取抑制剂作为辅助治疗来减轻 COVID-19 神经并发症的潜在益处。
