Department of Pharmacy, Anqing Medical College, Anqing, China.
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
J Food Biochem. 2020 Dec;44(12):e13510. doi: 10.1111/jfbc.13510. Epub 2020 Oct 6.
Pneumonia refers to a death-causing infection. Astragali Radix (AR) and Atractylodis Macrocephalae Rhizoma (AMR) are widely used as traditional tonic and promising edible immunomodulatory herbal medicine, but the systemic mechanism is not well understood. Therefore, a strategy based on network pharmacology and molecular docking was designed to explore the systemic mechanism of AR-AMR acting on pneumonia. After a series of bioinformatics assays, seven kernel targets were obtained, including TNF, IL6, IFNG, IL1B, IL10, IL4, and TLR9. And seven key compounds were identified as the synergy components of AR-AMR acting on pneumonia, the four key compounds belonging to AR were (3R)-3-(2-hydroxy-3,4-dimethoxyphenyl)-7-chromanol, formononetin, quercetin, and kaempferol, the three key compounds belonging to AMR were atractylone, 14-acetyl-12-senecioyl-2E, 8E, 10E-atractylentriol, and α-Amyrin. The crucial pathways were mainly related to three modules, including immune diseases, infectious disease, and organismal systems. Collectively, these observations strongly suggest that the molecular mechanisms of AR-AMR regulating pneumonia were closely related to the correlation between inflammation and immune response. PRACTICAL APPLICATIONS: Astragali radix and Atractylodis macrocephalae rhizoma can be used as "medicine-food homology" for dietary supplement. AR and AMR are widely used as a traditional tonic and promising edible immunomodulatory herbal medicine. The AR-AMR herb pairs are used for compatibility many times in the recommended prescriptions in COVID-19 develop pneumonia in China. However, the ingredients and mechanisms of AR-AMR acting on Pneumonia via immunomodulation are unclear. In this paper, bioinformatics and network biology were used to systematically explore the mechanisms of the AR-AMR herb pairs in treatment of pneumonia, and further analyze the correlation mechanism between it and COVID-19 develop pneumonia. To sum up, our study reveals the interrelationships between components, targets, and corresponding biological processes of AR-AMR acting on pneumonia. Understanding these relationships may provide guidance and theoretical basis for the further application of AR-AMR herb pairs.
肺炎是一种致命的感染。黄芪（AR）和白术（AMR）被广泛用作传统的滋补品和有前途的食用免疫调节剂草药，但系统机制尚不清楚。因此，设计了一种基于网络药理学和分子对接的策略，以探索 AR-AMR 对肺炎的系统作用机制。经过一系列生物信息学检测，得到了 7 个核心靶点，包括 TNF、IL6、IFNG、IL1B、IL10、IL4 和 TLR9。并鉴定出 7 种关键化合物作为 AR-AMR 作用于肺炎的协同成分，其中 4 种关键化合物属于 AR，分别为（3R）-3-（2-羟基-3,4-二甲氧基苯基）-7-色醇、芒柄花素、槲皮素和山奈酚，3 种关键化合物属于 AMR，分别为苍术酮、14-乙酰-12-千里光酰基-2E,8E,10E-千里光三醇和α-香树脂醇。关键途径主要与三个模块相关，包括免疫疾病、传染病和机体系统。总的来说，这些观察结果强烈表明，AR-AMR 调节肺炎的分子机制与炎症和免疫反应之间的相关性密切相关。实际应用：黄芪和白术可作为“药食同源”的膳食补充剂。AR 和 AMR 被广泛用作传统补品和有前途的食用免疫调节剂草药。在中国，AR-AMR 草药对被多次用于推荐的 COVID-19 发展为肺炎的处方中。然而，AR-AMR 对肺炎的作用机制及其通过免疫调节作用尚不清楚。本文利用生物信息学和网络生物学系统地探讨了 AR-AMR 对肺炎作用的机制，并进一步分析了其与 COVID-19 发展为肺炎的相关性机制。总之，我们的研究揭示了 AR-AMR 对肺炎作用的成分、靶点和相应生物学过程之间的相互关系。了解这些关系可能为进一步应用 AR-AMR 草药对提供指导和理论依据。
