Dong Qianyu, Li Zhen, Zhang Qian, Hu Yueyu, Liang Huazheng, Xiong Lize
Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Shanghai, China.
Clinical Research Center for Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Pharmacol. 2022 Jun 28;13:924429. doi: 10.3389/fphar.2022.924429. eCollection 2022.
Bunge (Fabaceae) (also known as -AR), a widely used herb by Traditional Chinese Medicine practitioners, possesses a wide range of pharmacological effects, and has been used to treat Alzheimer's disease (AD) historically. Its bioactive compounds are categorized into four families: saponins, flavonoids, polysaccharides, and others. AR's bioactive compounds are effective in managing AD through a variety of mechanisms, including inhibiting Aβ production, aggregation and tau hyperphosphorylation, protecting neurons against oxidative stress, neuroinflammation and apoptosis, promoting neural stem cell proliferation and differentiation and ameliorating mitochondrial dysfunction. This review aims to shed light upon the chemical constituents of AR and the mechanisms underlying the therapeutic effect of each compound in manging AD. Also presented are clinical studies which reported successful management of AD with AR and other herbs. These will be helpful for drug development and clinical application of AR to treat AD.
远志（豆科）（也称为 -AR）是中医从业者广泛使用的一种草药，具有广泛的药理作用，历史上一直用于治疗阿尔茨海默病（AD）。其生物活性化合物分为四类：皂苷、黄酮类、多糖和其他。AR 的生物活性化合物通过多种机制有效治疗 AD，包括抑制 Aβ 产生、聚集和 tau 过度磷酸化，保护神经元免受氧化应激、神经炎症和细胞凋亡，促进神经干细胞增殖和分化以及改善线粒体功能障碍。本综述旨在阐明 AR 的化学成分以及每种化合物治疗 AD 的作用机制。还介绍了报道 AR 和其他草药成功治疗 AD 的临床研究。这些将有助于 AR 治疗 AD 的药物开发和临床应用。
