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病例报告:孢子丝菌病患者的Sweet 综合征:10 例系列。

Case Report: Sweet Syndrome in Patients with Sporotrichosis: A 10-Case Series.

机构信息

1Federal University of Pernambuco, Recife, Brazil.

2Hospital of Clinics, Federal University of Pernambuco, Recife, Brazil.

出版信息

Am J Trop Med Hyg. 2020 Dec;103(6):2533-2538. doi: 10.4269/ajtmh.20-0579. Epub 2020 Oct 1.

Abstract

Human sporotrichosis is an emerging disease caused by fungi of the genus , distributed worldwide, but mostly in tropical and subtropical regions. This disease is caused by traumatic inoculation of contaminated material (either animal or vegetal in origin) into the skin. Sporotrichosis cases caused by zoonotic transmission through felines have significantly increased over the last 20 years in Brazil. There is a spectrum of clinical outcomes, from classical lymphocutaneous and fixed forms to disseminated manifestations and extracutaneous lesions; however, hypersensitivity reactions related to sporotrichosis, including Sweet syndrome (acute febrile neutrophilic dermatoses), are uncommon. In Brazil, is repeatedly associated with feline infection and has consistently shown higher virulence, tendency to escalate to outbreaks or epidemics, and development of atypical forms. Therefore, the objective of the present study was to report the cases of 10 patients with sporotrichosis infected by species who developed Sweet syndrome to alert this association, especially in endemic areas.

摘要

人类孢子丝菌病是一种由属真菌引起的新兴疾病,分布于世界各地,但主要在热带和亚热带地区。这种疾病是由受污染的物质(动物或植物来源)创伤性接种到皮肤引起的。在过去的 20 年中,巴西因猫科动物传播引起的动物源孢子丝菌病病例显著增加。临床表现多样,从经典的淋巴管皮肤和固定形式到播散性表现和皮肤外病变;然而,与孢子丝菌病相关的过敏反应,包括Sweet 综合征(急性发热性中性粒细胞皮肤病)并不常见。在巴西, 与猫科动物感染反复相关,且表现出更高的毒力、倾向于爆发或流行、以及形成非典型形式。因此,本研究的目的是报告 10 例由 种感染引起的孢子丝菌病患者出现 Sweet 综合征的病例,以引起对此种关联的警惕,尤其是在流行地区。

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本文引用的文献

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Itraconazole in the Treatment of Nonfungal Cutaneous Diseases: A Review.伊曲康唑治疗非真菌性皮肤病:综述
Dermatol Ther (Heidelb). 2019 Jun;9(2):271-280. doi: 10.1007/s13555-019-0299-9. Epub 2019 Apr 30.
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Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission.孢子丝菌病的人畜共患病流行:从猫到人的传播
PLoS Pathog. 2017 Jan 19;13(1):e1006077. doi: 10.1371/journal.ppat.1006077. eCollection 2017 Jan.
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Sweet Syndrome: A Review and Update.Sweet综合征:综述与更新
Actas Dermosifiliogr. 2016 Jun;107(5):369-78. doi: 10.1016/j.ad.2015.12.001. Epub 2016 Jan 27.
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Hypersensitivity reaction to Sporothrix schenckii: erythema nodosum associated with sporotrichosis.
Rev Soc Bras Med Trop. 2015 Jul-Aug;48(4):504. doi: 10.1590/0037-8682-0111-2015.

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