National Reference Center for Kleine-Levin Syndrome, Paris, France.
Sorbonne-APHP, Pitie-Salpetriere University Hospital, Sleep Disorders Unit, Paris, France.
J Clin Sleep Med. 2021 Feb 1;17(2):329-332. doi: 10.5664/jcsm.8858.
Kleine-Levin syndrome is a rare neurological disease of unknown cause beginning typically during adolescence, characterized by remittent-relapsing episodes of severe hypersomnia associated with cognitive and behavioral disturbances. Triggering factors at Kleine-Levin syndrome onset include infection, sleep deprivation, as well as alcohol, drug, and substance intake. A young woman had 6 episodes over 2 years, including hypersomnia, confusion, derealization, cognitive impairment, anxiety, feeling of being scrutinized, anorexia (and sweet craving once) but no hypersexuality. The first episode started after a party where she experienced a complete, 4-hour-long blackout despite moderate alcohol intake. The patient suspected having been poisoned. Twenty-five months after the party, when Kleine-Levin syndrome was eventually diagnosed, her long hair was analyzed and exogenous γ-hydroxybutyrate was found in the tips (corresponding to the party time). This case illustrates the interest of looking for γ-hydroxybutyrate in the hair when Kleine-Levin syndrome starts after a party.
克莱恩-莱文综合征是一种罕见的病因不明的神经系统疾病，通常在青春期开始，其特征是严重嗜睡反复发作，伴有认知和行为障碍。克莱恩-莱文综合征发作的诱因包括感染、睡眠剥夺以及酒精、药物和物质摄入。一名年轻女性在 2 年内发作了 6 次，包括嗜睡、意识模糊、现实解体、认知障碍、焦虑、被监视感、厌食（有一次想吃甜食），但没有性欲亢进。第一次发作是在一次聚会上，尽管她只喝了中等量的酒，但却完全昏迷了 4 个小时。患者怀疑自己被下了毒。在聚会 25 个月后，即最终诊断为克莱恩-莱文综合征时，对她的长发进行了分析，发梢中发现了外源性 γ-羟基丁酸（对应于聚会时间）。本病例说明了在聚会后出现克莱恩-莱文综合征时，在头发中寻找 γ-羟基丁酸的意义。
