Pediatric Department, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
Nutrition and Food Science, University of Tabuk, Tabuk, Saudi Arabia.
Prim Care Diabetes. 2022 Feb;16(1):102-106. doi: 10.1016/j.pcd.2021.09.002. Epub 2021 Sep 21.
We aimed to demonstrate the relationship between parental consanguinity and positive family histories of type 1 diabetes mellitus (T1DM) and autoimmune disease and the development of T1DM among children in Saudi Arabia.
This was a cross-sectional case-control study. In total, 192 patients and 188 healthy controls were enrolled from the Pediatric Diabetes Clinic at King Salman Military Hospital between January 2000 and December 2010. Detailed patients' data recorded while distributing questionnaires to control samples included various gradations of consanguinity and family histories of T1DM and autoimmune disease.
Parental consanguinity was not significantly associated with T1DM; however, children of first-cousin parents showed a higher risk of developing T1DM than did children of second-cousin parents. The presence of a family history of T1DM significantly differed between those with and without T1DM (p < 0.05). No association was observed between a family history of autoimmune disorders and the development of T1DM.
Parental consanguinity and family history of autoimmunity were not clearly linked to T1DM development in children, indicating that T1DM is a multifactorial disease. A history of affected first-cousin parents increases the risk of T1DM.
本研究旨在展示父母近亲结婚以及 1 型糖尿病（T1DM）和自身免疫性疾病阳性家族史与沙特阿拉伯儿童 T1DM 发病之间的关系。
这是一项横断面病例对照研究。2000 年 1 月至 2010 年 12 月，我们在 King Salman 军事医院儿科糖尿病诊所共纳入了 192 例患者和 188 例健康对照。在向对照样本分发问卷时，详细记录了患者的各项数据，包括近亲结婚的不同程度以及 T1DM 和自身免疫性疾病的家族史。
父母近亲结婚与 T1DM 无显著相关性；然而，父母为表亲的儿童比父母为堂亲的儿童发生 T1DM 的风险更高。T1DM 患者与非 T1DM 患者之间 T1DM 家族史的存在差异显著（p<0.05）。自身免疫性疾病家族史与 T1DM 的发病无相关性。
父母近亲结婚和自身免疫性疾病家族史与儿童 T1DM 发病无明显关联，表明 T1DM 是一种多因素疾病。有患 T1DM 的近亲父母会增加 T1DM 的发病风险。
