Programa de Pós-Graduação em Assistência e Avaliação em Saúde, Universidade Federal de Goiás (UFG). Av. Rúda Quadra 41A, Lote 10, Vila Brasília. 74905-760 Aparecida de Goiânia GO Brasil.
Instituto de Patologia Tropical e Saúde Pública, Departamento de Saúde Coletiva, UFG. Goiânia GO Brasil.
Cien Saude Colet. 2020 Oct;25(suppl 2):4121-4130. doi: 10.1590/1413-812320202510.2.26802020. Epub 2020 Aug 12.
Severe Acute Respiratory Infection (SARI) is a notifiable syndrome that must be investigated. This study aimed to analyze the epidemiological profile and factors associated with SARI-related hospitalization and deaths reported in Goiás. Retrospective cohort study, with data from the investigation files of the Notifiable Diseases Information System's Influenza Web. Multivariate analysis methods were employed to verify the association between exposure variables with the outcomes of ICU admission and death. A total of 4,832 SARI cases were reported in Goiás from 2013 to 2018. The primary etiological diagnosis was Influenza A (22.3%) with the predominant subtype A (H1N1pdm09), followed by the Respiratory Syncytial Virus. A total of 34.6% of the patients required ICU admission, and 19% died. A longer time to start treatment with antivirals was associated with a higher likelihood to have an ICU admission, while a previous non-vaccination against Influenza, longer time to start treatment, and older age were associated with a higher likelihood to suffer death. The study showed a high frequency of respiratory diseases caused by the Influenza virus in Goiás and that the severity of the syndrome, characterized by ICU admission and deaths, is associated with the start of antiviral treatment vaccine status, and patient's age.
严重急性呼吸道感染（SARI）是一种必须调查的法定报告综合征。本研究旨在分析戈亚斯州报告的与 SARI 相关的住院和死亡的流行病学特征及相关因素。这是一项回顾性队列研究，数据来自法定传染病信息系统流感网络的调查档案。采用多变量分析方法来验证暴露变量与入住 ICU 和死亡结局之间的关联。2013 年至 2018 年期间，戈亚斯州共报告了 4832 例 SARI 病例。主要病因诊断为流感 A（22.3%），主要亚型为 A（H1N1pdm09），其次为呼吸道合胞病毒。共有 34.6%的患者需要入住 ICU，19%死亡。抗病毒治疗开始时间延长与入住 ICU 的可能性增加相关，而既往未接种流感疫苗、治疗开始时间延长以及年龄较大与死亡可能性增加相关。本研究表明，戈亚斯州由流感病毒引起的呼吸道疾病发生率较高，而该综合征的严重程度，以入住 ICU 和死亡为特征，与抗病毒治疗开始时间、疫苗接种状况和患者年龄有关。
