Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
Angew Chem Int Ed Engl. 2021 Jan 25;60(4):2149-2154. doi: 10.1002/anie.202012344. Epub 2020 Nov 27.
A chromium-catalyzed dimerization/hydroboration of allenes is developed to access synthetically versatile boryl-functionalized skipped dienes with a catalyst generated in situ from CrCl and a pyridine-2,6-diimine ligand PDI. A variety of allenes reacted with pinacolborane (HBpin) to afford the corresponding boryl-functionalized (E,Z)-1,4-dienes in high yields and with excellent selectivity. Electron paramagnetic resonance (EPR) spectroscopic studies suggest that this chromium-catalyzed reaction probably proceeds through a chromium(I) hydride intermediate.
开发了一种铬催化的丙二烯二聚/硼氢化反应，以原位生成的 CrCl 和吡啶-2,6-二亚胺配体 PDI 为催化剂，合成具有多功能硼基官能化的 skipped dienes。各种丙二烯与频哪醇硼烷（HBpin）反应，以高收率和优异的选择性得到相应的硼基官能化的（E,Z）-1,4-二烯。电子顺磁共振（EPR）光谱研究表明，该铬催化反应可能通过铬（I）氢化物中间体进行。
