School of Medicine, National Defense Medical Center, Taipei 114, Taiwan.
School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan.
Medicina (Kaunas). 2020 Oct 5;56(10):521. doi: 10.3390/medicina56100521.
The clinical spectrum of novel coronavirus infection appears to be wide, encompassing asymptomatic infection, mild upper respiratory tract illness, and severe viral pneumonia, with respiratory failure and even death. Autoantibodies, especially antiphospholipid antibodies, can occur in severe infections. Other autoantibodies are seldom reported. Here, a 60-year-old female patient without dry-mouth symptoms detected positive for anti-60 kDa SSA/Ro antibodies on day 43 after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To investigate this unique clinical case of SARS-CoV-2 infection, immunological characteristics of this case were detected by using flow cytometry and were compared to the other three groups of patients-health subjects, 2019 novel coronavirus disease (COVID-19) recovery patients, and Sjögren's syndrome (SS) patients. Monitoring the autoantibody level and the development of subsequently related autoimmune diseases are warranted after SARS-CoV-2 infection.
新型冠状病毒感染的临床表现谱似乎很广，包括无症状感染、轻度上呼吸道疾病和严重病毒性肺炎，可导致呼吸衰竭甚至死亡。严重感染时可能会出现自身抗体，特别是抗磷脂抗体。其他自身抗体很少见报道。这里报告 1 例 60 岁女性患者，无口干症状，在严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染后第 43 天检测到抗 60kDa SSA/Ro 抗体阳性。为了研究这例 SARS-CoV-2 感染的独特临床病例，通过流式细胞术检测了该病例的免疫学特征，并与其他三组患者（健康受试者、2019 年新型冠状病毒病（COVID-19）康复患者和干燥综合征（SS）患者）进行了比较。SARS-CoV-2 感染后需要监测自身抗体水平和随后相关自身免疫性疾病的发展。
