Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Biomolecules. 2020 Oct 5;10(10):1409. doi: 10.3390/biom10101409.
Interleukin 37 () is an anti-inflammatory cytokine involved in the regulation of cholesterol homeostasis, reducing the levels of plasma cholesterol, fatty acids, and triglycerides. The aim of the present study was to evaluate the association of the IL-37 polymorphisms with the presence of hypercholesterolemia (HC), and with cardiovascular risk factors. Nine IL-37 polymorphisms (rs2708965, rs2708962, rs6717710, rs2708961, rs2708960, rs2708958, rs2723187, rs2708947, and rs2723192) were determined by TaqMan assays in a group of 1292 individuals (514 with and 778 without hypercholesterolemia) belonging to the cohort of the GEA Mexican Study. The associations were evaluated by logistic regression, using inheritance models adjusted by confounding variables. Under codominant 1 model, the rs2708961 (OR = 0.51, = 0.02), rs2723187 (OR = 0.35, = 0.005), and rs2708947 (OR = 0.49, = 0.02) polymorphisms were associated with low risk of HC. The association of the polymorphisms with cardiovascular risk factors was evaluated independently in HC and non-HC individuals. In non-HC individuals, some polymorphisms were associated with the risk of having high levels of LDL-C, glucose, and high risk of T2DM, and low risk of having high visceral abdominal fat. On the other hand, in individuals with HC five, polymorphisms were associated with high levels of C-reactive protein. The rs2708961, rs2723187, rs2708947 polymorphisms were associated with low risk of HC, and some polymorphisms were associated with cardiometabolic factors in both individuals with and without HC.
白细胞介素 37 () 是一种抗炎细胞因子，参与胆固醇稳态的调节，降低血浆胆固醇、脂肪酸和甘油三酯水平。本研究旨在评估 IL-37 多态性与高胆固醇血症 (HC) 之间的关系，以及与心血管危险因素之间的关系。在属于 GEA 墨西哥研究队列的 1292 名个体（514 名患有高胆固醇血症和 778 名无高胆固醇血症）中，通过 TaqMan 分析确定了 9 个 IL-37 多态性（rs2708965、rs2708962、rs6717710、rs2708961、rs2708960、rs2708958、rs2723187、rs2708947 和 rs2723192）。通过调整混杂变量的遗传模型，采用逻辑回归评估关联。在共显性 1 模型下，rs2708961（OR=0.51， = 0.02）、rs2723187（OR=0.35， = 0.005）和 rs2708947（OR=0.49， = 0.02）多态性与 HC 低风险相关。在 HC 和非 HC 个体中，独立评估了多态性与心血管危险因素的关系。在非 HC 个体中，一些多态性与 LDL-C、葡萄糖水平升高、T2DM 高危和内脏腹部脂肪减少的风险相关。另一方面，在患有 HC 的个体中，有五个多态性与 CRP 水平升高相关。rs2708961、rs2723187 和 rs2708947 多态性与 HC 低风险相关，一些多态性与 HC 和非 HC 个体的心血管代谢因素相关。
