Bonilla Carlos E, Perez Lugo Lucy M, Vallejo Yepes Camilo, Osma Charris Handerson R
Oncology, Instituto Nacional De Cancerología, Bogota, COL.
Internal Medicine, Instituto Nacional De Cancerología, Bogota, COL.
Cureus. 2020 Sep 1;12(9):e10179. doi: 10.7759/cureus.10179.
We present the case of a 21-year-old male patient with a history of monophasic synovial sarcoma in his left thigh, which was treated with surgical resection, radiotherapy, and chemotherapy with mesna, doxorubicin, and Ifosfamide (MAI protocol). Approximately six years after the end of the oncological treatment, he presented a nodular, polypoid lesion in the left popliteal region, which was painless and fast growing. Ultimately, the biopsy was consistent with atypical vascular proliferation (AVP). Vascular lesions after radiotherapy include a wide spectrum of pathologies that range from benign lesions such as AVP to malignant ones with very poor prognosis such as angiosarcoma, the distinction between one and the other can be difficult, being the determination rearrangement or amplification of gene c-myc, a key to make an accurate diagnosis in case of doubt.
我们报告了一名21岁男性患者的病例，该患者左大腿有单相滑膜肉瘤病史，接受了手术切除、放疗以及使用美司钠、多柔比星和异环磷酰胺的化疗（MAI方案）。肿瘤治疗结束约六年后，他在左腘窝区域出现了一个结节状、息肉样病变，无痛且生长迅速。最终，活检结果与非典型血管增生（AVP）相符。放疗后的血管病变包括从AVP等良性病变到预后极差的血管肉瘤等恶性病变的广泛病理类型，区分两者可能很困难，而基因c-myc的重排或扩增检测是在有疑问时做出准确诊断的关键。
