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喉内放疗后出现的非典型血管病变/血管肉瘤

Post-radiation atypical vascular lesion/angiosarcoma arising in the larynx.

作者信息

Mudaliar K M, Borrowdale R, Mehrotra S

机构信息

Department of Pathology, Loyola University Medical Center, Loyola University Chicago, Building #110, Rm #2242, 2160 S. First Avenue, Maywood, IL, 60153, USA,

出版信息

Head Neck Pathol. 2014;8(3):359-63. doi: 10.1007/s12105-013-0511-7. Epub 2013 Dec 6.

DOI:10.1007/s12105-013-0511-7
PMID:24310944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4126914/
Abstract

Atypical vascular lesions (AVL) and angiosarcomas (AS) are lesions known to arise after radiation therapy. These lesions can show overlap in both their gross and histologic pictures, and distinction between the two can be extremely challenging at times. They are known most commonly to arise in the breast region after radiation therapy. We present the first unique case of post-radiation AVL/AS arising in the larynx of a 51 year old woman, occurring 8 years after she received radiation for tonsillar squamous cell carcinoma.

摘要

非典型血管病变(AVL)和血管肉瘤(AS)是已知在放射治疗后出现的病变。这些病变在大体和组织学图像上可能会有重叠,有时两者之间的区分极具挑战性。它们最常见于放射治疗后的乳腺区域。我们报告了首例发生在一名51岁女性喉部的放射后AVL/AS独特病例,该病例发生在她因扁桃体鳞状细胞癌接受放疗8年后。

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本文引用的文献

1
c-myc and cutaneous vascular neoplasms.c-myc与皮肤血管肿瘤
Am J Dermatopathol. 2013 May;35(3):364-9. doi: 10.1097/DAD.0b013e31827aad83.
2
FISH for MYC amplification and anti-MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations.用于MYC扩增检测的荧光原位杂交技术及抗MYC免疫组织化学:评估继发性血管肉瘤和非典型血管增生的有用诊断工具。
J Cutan Pathol. 2012 Feb;39(2):234-42. doi: 10.1111/j.1600-0560.2011.01843.x. Epub 2011 Nov 29.
3
Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases.乳腺癌治疗后放射性皮肤血管肉瘤的特征是 MYC 扩增,与放疗后和对照病例的非典型血管病变不同:66 例的临床病理、免疫组化和分子分析。
Mod Pathol. 2012 Jan;25(1):75-85. doi: 10.1038/modpathol.2011.134. Epub 2011 Sep 9.
4
Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions.在放射性血管肉瘤中存在一致的 MYC 和 FLT4 基因扩增,但在其他放射性相关的非典型血管病变中不存在。
Genes Chromosomes Cancer. 2011 Jan;50(1):25-33. doi: 10.1002/gcc.20827.
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Postradiation cutaneous vascular tumors of the breast: a review.乳房放射性皮肤血管肿瘤:综述。
Semin Diagn Pathol. 2009 Aug;26(3):141-9. doi: 10.1053/j.semdp.2009.10.001.
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MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema.在辐射或慢性淋巴水肿后,MYC 高水平基因扩增是血管肉瘤的一个显著特征。
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Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases.放射性皮肤非典型血管病变与血管肉瘤:42例临床病理分析
Am J Surg Pathol. 2005 Aug;29(8):983-96.
10
Benign lymphangiomatous papules of the skin.皮肤良性淋巴管瘤性丘疹
J Am Acad Dermatol. 2005 May;52(5):912-3. doi: 10.1016/j.jaad.2005.01.129.