Saunders J H, Cargill J M, Wormsley K G
Digestion. 1977;15(5):452-6. doi: 10.1159/000198033.
Cimetidine inhibited nocturnal secretion of acid but only slightly inhibited the nocturnal secretion of pepsin in patients with duodenal ulcer. Administration of cimetidine (200 or 400 mg), together with an anticholinergic drug (poldine), augmented the inhibition of the nocturnal secretion of acid and of pepsin. The combination of an H2-receptor-blocking drug with an anticholinergic drug will have therapeutic application in the management of duodenal ulceration.
西咪替丁可抑制十二指肠溃疡患者夜间胃酸分泌，但对夜间胃蛋白酶分泌仅有轻微抑制作用。给予西咪替丁（200或400毫克）并联合使用抗胆碱能药物（甲哌佐酯），可增强对夜间胃酸和胃蛋白酶分泌的抑制作用。H2受体阻断药与抗胆碱能药物联合应用在十二指肠溃疡的治疗中具有应用价值。
