Londong W, Londong V, Ruthe C, Weizert P
Gut. 1981 Jul;22(7):542-8. doi: 10.1136/gut.22.7.542.
In a double-blind, placebo controlled and randomised secretory study the effectiveness of pirenzepine, ranitidine, and their combination was compared intraindividually in eight healthy subjects receiving intravenous bolus injections. Pirenzepine (0.15 mg/kg) plus ranitidine (0.6 mg/kg) suppressed peptone-stimulated gastric acid secretion from 69 +/- 11 to 2 +/- 0.4 mmol H+/3 h; the mean percentage inhibition was 97%. Postprandial gastrin was unaffected. There were only minor side-effects in a few experiments (reduction of salivation, brief blurring of vision), but no prolactin stimulation after ranitidine or ranitidine plus pirenzepine. The combined application of ranitidine and pirenzepine inhibited meal-stimulated acid secretion more effectively and produced fewer side-effects than the combination of cimetidine plus pirenzepine studied previously.
在一项双盲、安慰剂对照的随机分泌研究中,对8名接受静脉推注的健康受试者进行了哌仑西平、雷尼替丁及其联合用药的个体内有效性比较。哌仑西平(0.15mg/kg)加雷尼替丁(0.6mg/kg)可将蛋白胨刺激的胃酸分泌从69±11mmol H⁺/3h抑制至2±0.4mmol H⁺/3h;平均抑制率为97%。餐后胃泌素未受影响。在少数实验中仅有轻微副作用(唾液分泌减少、短暂视力模糊),但雷尼替丁或雷尼替丁加哌仑西平用药后未出现催乳素刺激。与先前研究的西咪替丁加哌仑西平联合用药相比,雷尼替丁和哌仑西平联合应用更有效地抑制了进餐刺激的胃酸分泌,且副作用更少。