西咪替丁对十二指肠溃疡近端胃迷走神经切断术前、后五肽胃泌素刺激的胃分泌的影响。

Effect of cimetidine on pentagastrin-stimulated gastric secretion before and after proximal gastric vagotomy for duodenal ulcer.

作者信息

Aadland E, Berstad A, Semb L S, Bjerke K

出版信息

Scand J Gastroenterol. 1978;13(6):679-84. doi: 10.3109/00365527809181781.

Abstract

Nine patients with duodenal ulcer were studied before and 2--3 months after proximal gastric vagotomy (PGV). Infustion or cimetidine, 1.2 mg.kg-1h-1, reduced mean gastric acid output, in response to infusion of 1.5 microgram.kg-1h-1 of pentagastrin, by, on an average, 79.4% before and 79.1% after vagotomy. The corresponding values for pepsin output were 66.5% before and 77.0% after the operation. The values were not statistically different. Thus, in terms of per cent inhibition, cimetidine was similarly effective before and after PGV. No correlation was found between per cent reduction of acic output by vagotomy and by cimetidine. The effect of the drug was added to that of the vagotomy. Patients with relapse ulcer after vagotomy are therefore interesting candidates for cimetidine treatment.

摘要

对9例十二指肠溃疡患者在近端胃迷走神经切断术（PGV）前后进行了研究。静脉输注西咪替丁，剂量为1.2mg·kg-1·h-1，在静脉输注1.5μg·kg-1·h-1的五肽胃泌素后，平均胃酸分泌量在迷走神经切断术前平均降低79.4%，术后降低79.1%。胃蛋白酶分泌量的相应数值在术前为66.5%，术后为77.0%。这些数值无统计学差异。因此，就抑制百分比而言，西咪替丁在PGV前后效果相似。未发现迷走神经切断术和西咪替丁降低胃酸分泌量的百分比之间存在相关性。药物的作用与迷走神经切断术的作用相加。因此，迷走神经切断术后复发溃疡的患者是西咪替丁治疗的有趣候选者。