Sober A J
Photodermatol. 1987 Feb;4(1):23-31.
Several lines of evidence suggest a role for solar exposure in the etiology of cutaneous melanoma. Increased incidence rates in light-complexioned, easily burning, poor tanning individuals; lower rates in Blacks and Orientals; higher rates geographically within countries as the equator is approached; and site differences by sex, which appear to be related to clothing differences, all support a role for solar exposure. Migration data and case control studies have emphasized the importance of intense exposures early in life rather than cumulative total lifetime exposure, which appears to be more important with the nonmelanoma forms of skin cancer. With the recognition of dysplastic nevi as precursors to melanoma, the causation of melanoma appears multifactored. The mechanisms by which sunlight may be involved in melanoma etiology are considered.
多项证据表明日光照射在皮肤黑色素瘤的病因学中起作用。肤色浅、易晒伤、不易晒黑的个体发病率增加；黑人和东方人的发病率较低；在一个国家内，越靠近赤道地区发病率越高；以及按性别区分的发病部位差异，这似乎与着装差异有关，所有这些都支持日光照射起作用。移民数据和病例对照研究强调了生命早期强烈暴露的重要性，而非终生累积暴露，终生累积暴露对非黑色素瘤形式的皮肤癌似乎更为重要。随着发育异常痣被认为是黑色素瘤的前驱病变，黑色素瘤的病因似乎是多因素的。本文探讨了阳光可能参与黑色素瘤病因学的机制。
