Sukhanova E S, Kamenva S V
Genetika. 1977;13(2):292-9.
Effect of 3 uvs mutations (uvs 12, 19 and 25) on recombination processes in Aspergillus nidulans is studied. All the mutations are found either to affect the fertility of carp bodies and germination ability of askospores, or result in complete inability of heterokaryons to form cleistocarpia. Two mutations change the frequency of spontaneous meitotic crossing-over at pro-paba region of the chromosome I and do not affect the rate of mitotic recombination at w-centromeric region of the chromosome II: uvs 12 mutation increases, and uvs 19 mutation decreases the frequency of meiotic recombination. One mutation (uvs 25) decreases the rate of spontaneous mitotic crossing-over. All uvs mutations decrease the frequency of VU light induced mitotic recombination at w-centromeric region of the chromosome II. The data obtained, together with earlier reported characteristics of uvs mutants, suggest that recombination mechanisms in yeast participate in reparation processes more actively than in prokariotes. Different effects of the same uvs mutations on spontaneous frequency of meiotic and mitotic crossing-over draw to the conclusion that genetic control and molecular mechanisms of these processes in A. nidulans are not identical.
研究了3种uvs突变（uvs 12、19和25）对构巢曲霉重组过程的影响。发现所有突变要么影响子囊体的育性和子囊孢子的萌发能力，要么导致异核体完全无法形成闭囊壳。两种突变改变了染色体I原氨基苯甲酸区域自发减数分裂交换的频率，而不影响染色体II着丝粒区域有丝分裂重组的速率：uvs 12突变增加，uvs 19突变降低减数分裂重组的频率。一种突变（uvs 25）降低了自发有丝分裂交换的速率。所有uvs突变均降低了染色体II着丝粒区域紫外线诱导的有丝分裂重组频率。所获得的数据，连同先前报道的uvs突变体的特征，表明酵母中的重组机制比原核生物更积极地参与修复过程。相同的uvs突变对减数分裂和有丝分裂交换自发频率的不同影响得出结论，构巢曲霉中这些过程的遗传控制和分子机制并不相同。
