首例多功能人诱导多能干细胞异位病毒诱导模型可深入了解 RNA 病毒疾病。

Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, 48149, Münster, Germany.

Interdisciplinary Centre for Clinical Research (IZKF), Faculty of Medicine, University of Münster, 48149, Münster, Germany.

Sci Rep. 2020 Oct 8;10(1):16804. doi: 10.1038/s41598-020-72966-9.

A detailed description of pathophysiological effects that viruses exert on their host is still challenging. For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully controllable environment, giving rise for new applications for the scientific community.

详细描述病毒对宿主产生的病理生理影响仍然具有挑战性。我们首次报告了一种基于健康人类供体 iPS 细胞系的高度可控的病毒表达模型。所建立的病毒模型系统能够在完全可控的环境中实现剂量依赖性和高度本地化的 RNA 病毒表达，为科学界的新应用提供了可能。