State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China.
Laboratory of Neuropsychology and Human Neuroscience, The University of Hong Kong, Hong Kong, China.
Brain Imaging Behav. 2021 Aug;15(4):2031-2039. doi: 10.1007/s11682-020-00397-1. Epub 2020 Oct 8.
Increasing evidence has shown that positive affect enhances many aspects of daily functioning. Yet, how dispositional positive affect is represented in the intrinsic brain networks remains unclear. Here, we used resting-state functional Magnetic Resonance Imaging to test how trait positive and negative affect of an individual were associated with the intrinsic connectivity of brain regions within the salience and emotion network and the default mode network in 70 healthy young adults. We observed that positive affect was negatively associated with connectivity within the salience and emotion network, particularly with the bidirectional connections spanning the left anterior insula and left nucleus accumbens. For connections between the salience and emotion network and the rest of the brain, we observed that positive affect was negatively related to the connectivity between the right amygdala and the right middle temporal gyrus. Affect-based modulations of connectivity were specific to positive affect and to the salience and emotion network. Our findings highlight the critical role of salience and emotion network in the neural relations of positive affect, and lay the groundwork for future studies on modeling the connectivity of salience and emotion network to predict mental well-being.
越来越多的证据表明，积极情绪能增强日常生活的方方面面。然而，个体特质性积极情绪如何在大脑固有网络中表现仍不清楚。在这里，我们使用静息态功能磁共振成像来测试个体特质性积极和消极情绪与突显和情绪网络以及默认模式网络中脑区固有连接的关系。结果显示，积极情绪与突显和情绪网络内的连接呈负相关，与横跨左侧前岛叶和左侧伏隔核的双向连接尤其相关。对于突显和情绪网络与大脑其他部分之间的连接，我们发现积极情绪与右侧杏仁核和右侧中颞回之间的连接呈负相关。基于连接的情绪调节作用是特定于积极情绪和突显与情绪网络的。我们的研究结果突出了突显和情绪网络在积极情绪神经关系中的关键作用，为未来研究利用突显和情绪网络的连接来预测心理健康奠定了基础。
