社会认知测试可独立于执行功能区分行为变异型额颞叶痴呆与阿尔茨海默病。

Social Cognition Tests Can Discriminate Behavioral Variant Frontotemporal Dementia From Alzheimer's Disease Independently of Executive Functioning.

机构信息

Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

出版信息

Arch Clin Neuropsychol. 2021 Jul 19;36(5):831-837. doi: 10.1093/arclin/acaa084.

DOI:10.1093/arclin/acaa084

PMID:33034347

Abstract

OBJECTIVE

To investigate the accuracy of the Social and Emotional Assessment-short version (Mini-SEA) to differentiate subgroups of behavioral variant of frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) defined according to executive performance.

METHODS

bvFTD (n = 21), AD (n = 20), and healthy controls (HC, n = 23) underwent the Mini-SEA, comprising the Facial Emotion Recognition Test (FERT) and the faux-pas test. AD and bvFTD patients were classified according to their performance in the Frontal Assessment Battery into dysexecutive and nondysexecutive subgroups.

RESULTS

The area under the curve (AUC) values for the faux-pas test were 0.87 (dysexecutive-bvFTD vs. dysexecutive-AD) and 0.96 (non-dysexecutive-bvFTD vs. nondysexecutive-AD). The AUC values for FERT were 0.99 (dysexecutive-bvFTD vs. dysexecutive-AD) and 0.65 (nondysexecutive-bvFTD vs. nondysexecutive-AD); the AUC values for the Mini-SEA (total-score) were 0.95 (dysexecutive-bvFTD vs. dysexecutive-AD) and 0.88 (nondysexecutive-bvFTD vs. nondysexecutive-AD).

DISCUSSION

Social Cognition tests accurately distinguish bvFTD from AD regardless of the executive profile.

摘要

目的

研究社会和情感评估简表（Mini-SEA）在区分根据执行功能定义的行为变异额颞叶痴呆（bvFTD）和阿尔茨海默病（AD）亚组方面的准确性。

方法

bvFTD（n=21）、AD（n=20）和健康对照组（HC，n=23）接受 Mini-SEA 测试，包括面部表情识别测试（FERT）和 faux-pas 测试。根据 Frontal Assessment Battery 的表现，AD 和 bvFTD 患者被分为执行功能障碍亚组和非执行功能障碍亚组。

结果

faux-pas 测试的曲线下面积（AUC）值分别为 0.87（执行功能障碍-bvFTD 与执行功能障碍-AD）和 0.96（非执行功能障碍-bvFTD 与非执行功能障碍-AD）。FERT 的 AUC 值分别为 0.99（执行功能障碍-bvFTD 与执行功能障碍-AD）和 0.65（非执行功能障碍-bvFTD 与非执行功能障碍-AD）；Mini-SEA（总分）的 AUC 值分别为 0.95（执行功能障碍-bvFTD 与执行功能障碍-AD）和 0.88（非执行功能障碍-bvFTD 与非执行功能障碍-AD）。