Neurochirurgie, CHU de Limoges, Limoges, France.
CAPTuR, EA 3842, Université de Limoges, Limoges, France.
Infection. 2021 Apr;49(2):267-275. doi: 10.1007/s15010-020-01534-0. Epub 2020 Oct 9.
The effects of surgical site infections (SSI) after glioblastoma surgery on patient outcomes are understudied. The aim of this retrospective multicenter study was to evaluate the impact of SSI on the survival of glioblastoma patients.
Data from SSI cases after glioblastoma surgeries between 2009 and 2016 were collected from 14 French neurosurgical centers. Collected data included patient demographics, previous medical history, risk factors, details of the surgical procedure, radiotherapy/chemotherapy, infection characteristics, and infection management. Similar data were collected from gender- and age-paired control individuals.
We used the medical records of 77 SSI patients and 58 control individuals. 13 were excluded. Our analyses included data from 64 SSI cases and 58 non-infected glioblastoma patients. Infections occurred after surgery for primary tumors in 38 cases (group I) and after surgery for a recurrent tumor in 26 cases (group II). Median survival was 381, 633, and 547 days in patients of group I, group II, and the control group, respectively. Patients in group I had significantly shorter survival compared to the other two groups (p < 0.05). The one-year survival rate of patients who developed infections after surgery for primary tumors was 50%. Additionally, we found that SSIs led to postoperative treatment discontinuation in 30% of the patients.
Our findings highlighted the severity of SSIs after glioblastoma surgery, as they significantly affect patient survival. The establishment of preventive measures, as well as guidelines for the management of SSIs, is of high clinical importance.
胶质母细胞瘤手术后手术部位感染（SSI）对患者预后的影响研究不足。本回顾性多中心研究旨在评估 SSI 对胶质母细胞瘤患者生存的影响。
从 2009 年至 2016 年 14 家法国神经外科中心收集胶质母细胞瘤手术后 SSI 病例的数据。收集的数据包括患者人口统计学、既往病史、危险因素、手术细节、放疗/化疗、感染特征和感染管理。从性别和年龄匹配的对照组中收集类似的数据。
我们使用了 77 例 SSI 患者和 58 例对照个体的病历。排除了 13 例患者。我们的分析包括 64 例 SSI 病例和 58 例未感染的胶质母细胞瘤患者的数据。38 例（I 组）在原发性肿瘤手术后发生感染，26 例（II 组）在复发性肿瘤手术后发生感染。I 组、II 组和对照组患者的中位生存时间分别为 381、633 和 547 天。I 组患者的生存时间明显短于其他两组（p<0.05）。原发性肿瘤手术后发生感染的患者一年生存率为 50%。此外，我们发现 SSI 导致 30%的患者术后治疗中断。
我们的研究结果强调了胶质母细胞瘤手术后 SSI 的严重性，因为它显著影响患者的生存。建立预防措施以及 SSI 管理指南具有重要的临床意义。
