MLL-TFE3：一种在婴儿白血病中发现的新型侵袭性KMT2A融合基因。
MLL-TFE3: a novel and aggressive KMT2A fusion identified in infant leukemia.
作者信息
Kosasih Hansen J, Davidson Nadia M, Bjelosevic Stefan, Morrish Emma, Brennan Margs S, Oshlack Alicia, Johnstone Ricky W, Brumatti Gabriela, Khaw Seong L, Ekert Paul G
机构信息
Murdoch Children's Research Institute, Parkville, VIC, Australia.
Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
出版信息
Blood Adv. 2020 Oct 13;4(19):4918-4923. doi: 10.1182/bloodadvances.2020002708.
Abstract
A novel -rearrangement, MLL-TFE3, was identified in an infant leukemia patient. MLL-TFE3 expression produces aggressive leukemia in a mouse model.
摘要
在一名婴儿白血病患者中发现了一种新的重排——MLL-TFE3。MLL-TFE3的表达在小鼠模型中引发侵袭性白血病。
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