Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
Department of Neurosurgery, Toyama University, Toyama 930-0194, Japan.
Int J Mol Sci. 2020 Oct 6;21(19):7380. doi: 10.3390/ijms21197380.
Despite recent developments in innovative treatment strategies, stroke remains one of the leading causes of death and disability worldwide. Stem cell therapy is currently attracting much attention due to its potential for exerting significant therapeutic effects on stroke patients. Various types of cells, including bone marrow mononuclear cells, bone marrow/adipose-derived stem/stromal cells, umbilical cord blood cells, neural stem cells, and olfactory ensheathing cells have enhanced neurological outcomes in animal stroke models. These stem cells have also been tested via clinical trials involving stroke patients. In this article, the authors review potential molecular mechanisms underlying neural recovery associated with stem cell treatment, as well as recent advances in stem cell therapy, with particular reference to clinical trials and future prospects for such therapy in treating stroke.
尽管创新性治疗策略最近有了一些进展，但中风仍然是全球范围内导致死亡和残疾的主要原因之一。由于其对中风患者具有显著的治疗效果，干细胞疗法目前备受关注。各种类型的细胞，包括骨髓单核细胞、骨髓/脂肪源性干细胞/基质细胞、脐带血细胞、神经干细胞和嗅鞘细胞，已在动物中风模型中改善了神经功能结局。这些干细胞也已经在涉及中风患者的临床试验中进行了测试。在本文中，作者综述了与干细胞治疗相关的神经恢复的潜在分子机制，以及干细胞治疗的最新进展，特别提到了临床试验以及该疗法治疗中风的未来前景。
