Department of Neurology, Nippon Medical School, Tokyo 113-8602, Japan.
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
Int J Mol Sci. 2020 Sep 14;21(18):6718. doi: 10.3390/ijms21186718.
Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke.
中风是全球最常见的心血管疾病，也是死亡和残疾的主要原因之一。基于干细胞的疗法正被积极研究作为某些神经疾病（包括中风）的一种新的潜在治疗方法。已经发现各种类型的细胞，包括骨髓单核细胞、骨髓间充质干细胞、牙髓干细胞、神经干细胞、诱导多能干细胞和基因修饰的干细胞，可改善中风动物模型的神经功能结局，并且有一些正在进行的临床试验评估它们在人类中的疗效。在这篇综述中，我们旨在总结细胞疗法治疗中风的最新进展。
