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墨西哥城玉米糁中伏马菌素 B1、伏马菌素 B2 和脱氧雪腐镰刀菌烯醇的发生和概率风险评估。

Occurrence and Probabilistic Risk Assessment of Fumonisin B1, Fumonisin B2 and Deoxynivalenol in Nixtamalized Maize in Mexico City.

机构信息

Division of Toxicology, Wageningen University & Research, 6708 WE Wageningen, The Netherlands.

出版信息

Toxins (Basel). 2020 Oct 6;12(10):644. doi: 10.3390/toxins12100644.

Abstract

Fumonisins (FB1+FB2) and deoxynivalenol (DON) are mycotoxins produced by species that might be present in maize and maize products. Knowledge on their occurrence in nixtamalized maize from Mexico together with an accompanying risk assessment are scarce, while nixtamalized maize is an important food in Mexico. This study presents the occurrence of FB1 + FB2 and DON in nixtamalized maize samples collected in Mexico City and analyses their distribution and resulting estimated daily intake for Mexican consumers by a probabilistic approach using a two-dimensional Monte-Carlo simulation. The results obtained reveal that for FB1 + FB2, 47% of the Mexican men and 30% of the Mexican women might exceed the provisional tolerable daily intake (PMTDI) of 2 µg/kg bw/day for fumonisins and for DON, 9% of men and 5% of women would be exceeding the PMTDI of 1 µg/kg bw/day, corresponding to the high consumers. The results raise a flag for risk managers in Mexico, to consider regulations and interventions that lower mycotoxin levels in nixtamalized maize for human consumption.

摘要

伏马菌素(FB1+FB2)和脱氧雪腐镰刀菌烯醇(DON)是某些种类产生的真菌毒素,可能存在于玉米及其制品中。关于它们在墨西哥玉米粉蒸粗麦粉中的存在情况及其伴随的风险评估的知识很少,而玉米粉蒸粗麦粉是墨西哥的一种重要食品。本研究报告了在墨西哥城采集的玉米粉蒸粗麦粉样品中 FB1+FB2 和 DON 的出现情况,并采用二维蒙特卡罗模拟的概率方法分析了它们的分布情况,以及对墨西哥消费者的估计每日摄入量。结果表明,对于 FB1+FB2,47%的墨西哥男性和 30%的墨西哥女性可能超过伏马菌素暂定每日耐受摄入量(PMTDI)2µg/kg bw/天,对于 DON,9%的男性和 5%的女性将超过 1µg/kg bw/天的 PMTDI,这是高消费者的摄入量。这些结果为墨西哥的风险管理者敲响了警钟,需要考虑制定法规和采取干预措施,以降低人类食用玉米粉蒸粗麦粉中的真菌毒素水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/372f/7600745/9e4dfcd885e6/toxins-12-00644-g001.jpg

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