College of Health and Sport Science, Santa Catarina State University, Brazil.
College of Health and Sport Science, Santa Catarina State University, Brazil.
Maturitas. 2020 Nov;141:71-81. doi: 10.1016/j.maturitas.2020.06.022. Epub 2020 Jun 26.
Side-effects of hormone therapy can impair the physical health of breast cancer survivors. Exercise has been clearly shown to improve the quality of life of breast cancer survivors. Less is known about the effects of exercise on physical outcomes for breast cancer survivors receiving hormone therapy.
To investigate the effects of exercise on physical outcomes of breast cancer survivors receiving hormone therapy.
Five electronic databases were searched by two authors using the terms "Breast Neoplasms" [MeSH] and "Tamoxifen" [MeSH] and "Aromatase Inhibitors" [MeSH] and "Exercise" [MeSH]. Randomized and non-randomized clinical trials were included. Risk of bias was assessed by the Cochrane Collaboration tool and ROBINS-I, and the quality of evidence was evaluated using GRADE. Pooled effects were reported as standardized mean differences (SMDs) and 95 % confidence intervals (CIs) using a random effects model.
Eleven studies were included in the meta-analysis. Two hundred and fourteen breast cancer survivors receiving hormone therapy, tamoxifen, or aromatase inhibitors participated in interventions based on aerobic plus resistance exercise or walking activity. The physical outcomes reported in the articles were: cardiorespiratory fitness, pain, bone mineral density, grip strength, and body fat percentage. Exercise effects were found only for cardiorespiratory fitness (SMD = 0.37; 95 % CI: 0.11; 0.63; I = 93 %) and pain (SMD = -0.55; IC95 % -1.11; -0.00; I = 80 %), with low quality of evidence. No effects were observed for the other variables.
Aerobic plus resistance exercise had positive effects on cardiorespiratory fitness and pain in breast cancer survivors receiving hormone therapy. However, high-quality randomized clinical trials are required to confirm this finding.
激素治疗的副作用会损害乳腺癌幸存者的身体健康。运动已被明确证明可以提高乳腺癌幸存者的生活质量。然而，对于接受激素治疗的乳腺癌幸存者，运动对身体结果的影响知之甚少。
研究运动对接受激素治疗的乳腺癌幸存者身体结果的影响。
两位作者使用“乳腺肿瘤”[MeSH]和“他莫昔芬”[MeSH]和“芳香酶抑制剂”[MeSH]和“运动”[MeSH]这两个术语，对五个电子数据库进行了搜索。纳入了随机和非随机临床试验。使用 Cochrane 协作工具和 ROBINS-I 评估偏倚风险，并使用 GRADE 评估证据质量。使用随机效应模型报告汇总效应，结果表示为标准化均数差（SMD）和 95%置信区间（CI）。
11 项研究纳入荟萃分析。214 名接受激素治疗、他莫昔芬或芳香酶抑制剂治疗的乳腺癌幸存者参加了基于有氧运动加抗阻运动或散步活动的干预。文章中报告的身体结果包括心肺功能、疼痛、骨密度、握力和体脂百分比。运动的效果仅在心肺功能（SMD=0.37；95%CI：0.11；0.63；I=93%）和疼痛（SMD=-0.55；IC95%：-1.11；-0.00；I=80%）方面有发现，证据质量为低。其他变量没有观察到效果。
有氧运动加抗阻运动对接受激素治疗的乳腺癌幸存者的心肺功能和疼痛有积极影响。然而，需要高质量的随机临床试验来证实这一发现。
