Hirabayashi S, Ono Y, Ohshima S
Hinyokika Kiyo. 1987 Apr;33(4):501-7.
Natural cell-mediated cytotoxicity (NCMC) displayed by peripheral blood mononuclear cells of kidney allograft recipients was examined against K562 cells to demonstrate the kinetics of NCMC activity in the posttransplant period. On 44 kidney allograft recipients 301 NCMC assays were performed between 1 and 84 months after transplantation. These patients were treated with the conventional immunosuppressive treatment consisting of steroid and azathioprine. NCMC activity sharply decreased after transplant surgery. A decreased NCMC activity continued during the first 6 months and the mean NCMC value was 19.2 +/- 14.1. In the second 30 months, NCMC activity also constantly decreased, almost to 10. It was lower than that of the first 6 months (P less than 0.01). After 37 months, some patients restored a normal NCMC activity and others showed a decreased NCMC activity. The mean value was 27.4 +/- 20.6 in the third 48 months. The depression of NCMC activity might be caused by the large dose of steroid and azathioprine in the first 6 months. In the third 48 months, NCMC activity might be dependent on the dosage of azathioprine alone. The activation of NCMC activity might be caused by acute rejection crisis.
检测了肾移植受者外周血单个核细胞表现出的自然细胞介导的细胞毒性（NCMC），以研究移植后时期NCMC活性的动力学。对44例肾移植受者在移植后1至84个月期间进行了301次NCMC检测。这些患者接受了由类固醇和硫唑嘌呤组成的常规免疫抑制治疗。移植手术后NCMC活性急剧下降。在最初6个月内NCMC活性持续降低，NCMC平均值为19.2±14.1。在随后的30个月内，NCMC活性也持续下降，几乎降至10。低于最初6个月（P<0.01）。37个月后，一些患者恢复了正常的NCMC活性，而另一些患者NCMC活性降低。在第三个48个月内平均值为27.4±20.6。NCMC活性降低可能是由于最初6个月内大剂量的类固醇和硫唑嘌呤所致。在第三个48个月内，NCMC活性可能仅取决于硫唑嘌呤的剂量。NCMC活性的激活可能是由急性排斥反应危机引起的。
