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本文引用的文献

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Brain neutralization of rabies virus to distinguish recovered animals from previously vaccinated animals.狂犬病病毒的脑中和试验以区分康复动物和既往接种过疫苗的动物。
J Immunol. 1966 Dec;97(6):747-53.
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In vitro synthesis of IgG by cells from the cerebrospinal fluid in a patient with multiple sclerosis.多发性硬化症患者脑脊液细胞体外合成IgG
Clin Exp Immunol. 1969 Apr;4(4):401-5.
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The immune response in the hamster. V. Biologic activities of 7S-gamma-1 and 7S-gamma-2 globulins.仓鼠的免疫反应。V. 7S-γ-1和7S-γ-2球蛋白的生物学活性。
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Ultraviolet-light-irradiated vaccine.
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The relationship between immunity and the pathology of the CNS of mice infected with the CVS strain of rabies.感染狂犬病CVS株的小鼠免疫力与中枢神经系统病理学之间的关系。
Br J Exp Pathol. 1973 Oct;54(5):534-52.
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Biological activities of immunoglobulins of different classes and subclasses.不同类别和亚类免疫球蛋白的生物学活性
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7
Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis.亚急性硬化性全脑炎患者中枢神经系统中针对不同麻疹病毒抗原的寡克隆IgG抗体反应
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Local antibody response to experimental poliovirus infection in the central nervous system of rhesus monkeys.恒河猴中枢神经系统对实验性脊髓灰质炎病毒感染的局部抗体反应。
Infect Immun. 1973 Dec;8(6):931-7. doi: 10.1128/iai.8.6.931-937.1973.
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Immunoglobulin synthesis within the central nervous system in disseminated sclerosis.多发性硬化症中枢神经系统内的免疫球蛋白合成
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Immunoglobulin response to rabies vaccine in man.
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叙利亚仓鼠对狂犬病病毒的抗体反应。

Antibody response to rabies virus in Syrian hamsters.

作者信息

Coe J E, Bell J F

出版信息

Infect Immun. 1977 Jun;16(3):915-9. doi: 10.1128/iai.16.3.915-919.1977.

DOI:10.1128/iai.16.3.915-919.1977
PMID:330398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC421050/
Abstract

Syrian hamsters were injected with inactivated, attenuated, and virulent rabies virus (RV), and the antibody response was quantified by a neutralization test and the immunoglobulin class of the virus antibody was characterized by indirect fluorescent microscopy. Serum antibodies to RV were found to be predominantly of the immunoglobulin G2 (IgG2) class, although IgG1 anti-RV also were detected in high-titered sera obtained after secondary challenge. Brain extracts of hamsters inoculated intracerebrally with RV contained only IgG2 anti-RV. IgA and IgM anti-RV were not detected. The preferential IgG2 response to RV is in marked contrast to the isolated IgG1 response detected after inoculation of hamsters with soluble purified protein antigens.

摘要

给叙利亚仓鼠注射灭活、减毒和强毒狂犬病病毒（RV），通过中和试验对抗体反应进行定量，并通过间接荧光显微镜对病毒抗体的免疫球蛋白类别进行鉴定。发现针对RV的血清抗体主要为免疫球蛋白G2（IgG2）类别，不过在二次攻击后获得的高滴度血清中也检测到了IgG1抗RV。经脑内接种RV的仓鼠脑提取物中仅含有IgG2抗RV。未检测到IgA和IgM抗RV。对RV的优先IgG2反应与仓鼠接种可溶性纯化蛋白抗原后检测到的孤立IgG1反应形成显著对比。