叙利亚仓鼠对狂犬病病毒的抗体反应。
Antibody response to rabies virus in Syrian hamsters.
作者信息
Coe J E, Bell J F
出版信息
Infect Immun. 1977 Jun;16(3):915-9. doi: 10.1128/iai.16.3.915-919.1977.
Abstract
Syrian hamsters were injected with inactivated, attenuated, and virulent rabies virus (RV), and the antibody response was quantified by a neutralization test and the immunoglobulin class of the virus antibody was characterized by indirect fluorescent microscopy. Serum antibodies to RV were found to be predominantly of the immunoglobulin G2 (IgG2) class, although IgG1 anti-RV also were detected in high-titered sera obtained after secondary challenge. Brain extracts of hamsters inoculated intracerebrally with RV contained only IgG2 anti-RV. IgA and IgM anti-RV were not detected. The preferential IgG2 response to RV is in marked contrast to the isolated IgG1 response detected after inoculation of hamsters with soluble purified protein antigens.
摘要
给叙利亚仓鼠注射灭活、减毒和强毒狂犬病病毒（RV），通过中和试验对抗体反应进行定量，并通过间接荧光显微镜对病毒抗体的免疫球蛋白类别进行鉴定。发现针对RV的血清抗体主要为免疫球蛋白G2（IgG2）类别，不过在二次攻击后获得的高滴度血清中也检测到了IgG1抗RV。经脑内接种RV的仓鼠脑提取物中仅含有IgG2抗RV。未检测到IgA和IgM抗RV。对RV的优先IgG2反应与仓鼠接种可溶性纯化蛋白抗原后检测到的孤立IgG1反应形成显著对比。
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