Zavala Gerardo A, Prasad-Muliyala Krishna, Aslam Faiza, Barua Deepa, Haidar Asiful, Hewitt Catherine, Huque Rumana, Mansoor Sonia, Murthy Pratima, Nizami Asad T, Siddiqi Najma, Sikander Siham, Siddiqi Kamran, Boehnke Jan Rasmus
Department of Health Sciences, University of York, York, UK
Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangaluru, India.
BMJ Open. 2020 Oct 10;10(10):e037869. doi: 10.1136/bmjopen-2020-037869.
People with severe mental illness (SMI) die on average 10-20 years earlier than the general population. Most of these deaths are due to physical health conditions. The aim of this cross-sectional study is to determine the prevalence of physical health conditions and their associations with health-risk behaviours, health-related quality of life and various demographic, behavioural, cognitive, psychological and social variables in people with SMI attending specialist mental health facilities in South Asia.
We will conduct a survey of patients with SMI attending specialist mental health facilities in Bangladesh, India and Pakistan (n=4500). Diagnosis of SMI will be confirmed using the Mini-international neuropsychiatric interview V.6.0. We will collect information about physical health and related health-risk behaviours (WHO STEPwise approach to Surveillance (STEPS)); severity of common mental disorders (Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder scale (GAD-7)) and health-related quality of life (EQ-5D-5L). We will measure blood pressure, height, weight and waist circumference according to WHO guidelines. We will also measure glycated haemoglobin, lipid profile, thyroid function, liver function, creatinine and haemoglobin. Prevalence rates of physical health conditions and health-risk behaviours will be presented and compared with the WHO STEPS survey findings in the general population. Regression analyses will explore the association between health-risk behaviours, mental and physical health conditions.
The study has been approved by the ethics committees of the Department of Health Sciences University of York (UK), Centre for Injury Prevention and Rehabilitation (Bangladesh), Health Ministry Screening Committee and Indian Council of Medical Research (India) and National Bioethics Committee (Pakistan). Findings will be disseminated in peer-reviewed articles, in local and international conferences and as reports for policymakers and stakeholders in the countries involved.
ISRCTN88485933; 3 June 2019.
患有严重精神疾病（SMI）的人群平均比普通人群早10至20年死亡。这些死亡大多归因于身体健康状况。这项横断面研究的目的是确定在南亚专门的心理健康机构就诊的严重精神疾病患者中身体健康状况的患病率，以及这些状况与健康风险行为、健康相关生活质量以及各种人口统计学、行为学、认知、心理和社会变量之间的关联。
我们将对在孟加拉国、印度和巴基斯坦专门的心理健康机构就诊的严重精神疾病患者（n = 4500）进行一项调查。将使用《迷你国际神经精神访谈》V.6.0来确诊严重精神疾病。我们将收集有关身体健康及相关健康风险行为的信息（世界卫生组织逐步监测方法（STEPS））；常见精神障碍的严重程度（患者健康问卷 - 9（PHQ - 9）和广泛性焦虑障碍量表（GAD - 7））以及健康相关生活质量（EQ - 5D - 5L）。我们将根据世界卫生组织指南测量血压、身高、体重和腰围。我们还将测量糖化血红蛋白、血脂谱、甲状腺功能、肝功能、肌酐和血红蛋白。将呈现身体健康状况和健康风险行为的患病率，并与世界卫生组织在普通人群中的STEPS调查结果进行比较。回归分析将探讨健康风险行为与身心健康状况之间的关联。
该研究已获得英国约克大学健康科学系伦理委员会、孟加拉国伤害预防与康复中心、卫生部筛查委员会、印度医学研究理事会（印度）以及国家生物伦理委员会（巴基斯坦）的批准。研究结果将在同行评审文章、地方和国际会议上发表，并作为报告提供给相关国家的政策制定者和利益相关者。
ISRCTN88485933；2019年6月3日。
