Department of Otolaryngology, University Hospitals of Leicester NHS Trust, 3rd Floor Balmoral Building, Infirmary Square, Leicester, LE1 5WW, UK.
Eur Arch Otorhinolaryngol. 2021 Sep;278(9):3291-3297. doi: 10.1007/s00405-020-06416-7. Epub 2020 Oct 10.
To evaluate the relationship between the waiting time for surgery, and cholesteatoma recidivism rates and major complications. The secondary aims were to identify any other prognostic factors for cholesteatoma recidivism.
A retrospective single-centre study of 312 patients who underwent cholesteatoma surgery under the care of a single-surgeon, between 2004 and 2018, was performed. Waiting times for surgery were categorised into ≤ 90 days, 91-180 days, 181-270 days and > 271 days. The outcome measures were cholesteatoma recidivism and major complications (facial nerve palsy or intracranial complications).
The mean age was 36.1 years ± 21.5 with 242 adults (77.6%) and 70 children (22.4%). The mean waiting time for surgery was 126.2 days (4.1 months) ± 96.0 days and the overall rate of recidivism was 11.2% (35/312 patients). No instances of facial nerve palsy or intracranial complications were identified. Rates of recidivism by waiting time for surgery were: 15.3% for 118 patients who waited ≤ 90 days, 9.7% for 134 patients who waited 91-180 days, 6.7% for 30 patients who waited 181-270 days and 4.3% for 23 patients who waited > 271 days. There was no significant difference amongst the different waiting time groups for rates of recidivism (p = 0.266).
Increased waiting times for cholesteatoma surgery do not appear to be associated with increased rates of recidivism or major complications. Clinical judgement will always be required for complicated disease or patients with additional risk factors. The other prognostic factors for recidivism identified in this study were age (< 15 years) and congenital cholesteatoma.
评估手术等待时间与胆脂瘤复发率和主要并发症之间的关系。次要目的是确定胆脂瘤复发的其他任何预后因素。
对 2004 年至 2018 年间由同一位外科医生进行胆脂瘤手术的 312 例患者进行了回顾性单中心研究。手术等待时间分为≤90 天、91-180 天、181-270 天和>271 天。主要结局指标为胆脂瘤复发和主要并发症(面神经瘫痪或颅内并发症)。
患者平均年龄为 36.1 岁±21.5 岁,其中 242 例为成年人(77.6%),70 例为儿童(22.4%)。手术平均等待时间为 126.2 天(4.1 个月)±96.0 天,总复发率为 11.2%(35/312 例)。未发现面神经瘫痪或颅内并发症。手术等待时间与胆脂瘤复发率的关系如下:118 例等待时间≤90 天的患者复发率为 15.3%,134 例等待时间为 91-180 天的患者复发率为 9.7%,30 例等待时间为 181-270 天的患者复发率为 6.7%,23 例等待时间>271 天的患者复发率为 4.3%。不同等待时间组之间的复发率无显著差异(p=0.266)。
胆脂瘤手术等待时间的增加似乎与复发率或主要并发症的增加无关。对于复杂疾病或有其他危险因素的患者,仍需要临床判断。本研究确定的胆脂瘤复发的其他预后因素是年龄(<15 岁)和先天性胆脂瘤。