Postgraduate Program in Dentistry, Emphasis on Periodontics, Department of Stomatology, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil.
J Periodontol. 2021 Jun;92(6):793-802. doi: 10.1002/JPER.20-0200. Epub 2020 Oct 28.
Several studies have shown the relationship between periodontal disease and chronic kidney disease, but there is little evidence to assess the impact of the amount of inflamed periodontal tissue on the levels of systemic inflammatory markers. So the aim of this study is determine the association between high-sensitivity C-reactive protein (hsCRP) and both periodontitis and periodontal inflamed surface area (PISA) in adults with end-stage renal disease (ESRD).
Cross-sectional study was conducted with 176 adults with ESRD on regular hemodialysis. The participants were submitted to a full-mouth periodontal examination to determine the occurrence of periodontitis and PISA. Regression analysis was performed to test the independent association between periodontal conditions and serum hsCRP levels.
A total of 98.9% of the participants had periodontitis, with stages III and IV found in 26.1% and 52.9%, respectively. Mean hsCRP and PISA was 6.57 (SD: 6.03) mg/L and 217.15 (SD: 271.50), respectively. In the adjusted analysis, mean serum hsCRP levels were significantly higher in patients with stage III and IV generalized periodontitis compared with no/localized/generalized stages I-II (7.67 mg/L versus 5.72 mg/L, P = 0.028). After adjustments for confounding variables, individuals with PISA >490.56 mm (85th percentile) had a 3.26-fold greater chance of having hsCRP above 5 mg/L than their counterparts (OR = 3.26; 95% CI: 1.25 to 8.49).
The inflammatory burden imposed by periodontitis can increase serum hsCRP levels in adults with end-stage renal disease.
多项研究表明牙周病与慢性肾脏病之间存在关联，但很少有证据可以评估发炎的牙周组织量对全身炎症标志物水平的影响。因此，本研究旨在评估在终末期肾病（ESRD）患者中，高敏 C 反应蛋白（hsCRP）与牙周炎和牙周炎炎症表面面积（PISA）之间的相关性。
对 176 名接受常规血液透析的 ESRD 成年患者进行了横断面研究。对患者进行全口牙周检查，以确定牙周炎和 PISA 的发生情况。进行回归分析以检验牙周状况与血清 hsCRP 水平之间的独立相关性。
共有 98.9%的参与者患有牙周炎，其中 III 期和 IV 期分别占 26.1%和 52.9%。hsCRP 和 PISA 的平均值分别为 6.57（SD：6.03）mg/L 和 217.15（SD：271.50）。在调整后的分析中，与无/局部/广泛 I-II 期相比，III 期和 IV 期广泛性牙周炎患者的血清 hsCRP 水平明显更高（7.67 mg/L 与 5.72 mg/L，P=0.028）。在调整混杂因素后，PISA>490.56 mm（第 85 百分位数）的个体患 hsCRP>5 mg/L 的可能性是其对应个体的 3.26 倍（OR=3.26；95%CI：1.25 至 8.49）。
牙周炎引起的炎症负担可增加终末期肾病成年患者的血清 hsCRP 水平。
