系统锌与氧化应激水平与牙周炎炎症表面面积的关系。
Association between systemic zinc and oxidative stress levels and periodontal inflamed surface area.
机构信息
Department of Periodontology, Faculty of Dentistry, Hatay Mustafa Kemal University, Hatay, Turkiye.
Periodontology Unit, Centre for Host-Microbiome Interactions, King's College London Dental Institute, London, UK.
出版信息
Turk J Med Sci. 2024 Jul 7;54(5):915-923. doi: 10.55730/1300-0144.5868. eCollection 2024.
BACKGROUND/AIM: Zinc is a structural component of some enzymes. The aim of this study was to evaluate the potential associations between serum zinc and oxidative stress levels and periodontal inflamed surface area (PISA).
MATERIALS AND METHODS
This study included 90 patients divided into three groups: a periodontitis group (P; n = 30), a gingivitis group (G; n = 30), and a periodontal health group (PH; n = 30). Periodontal parameters were recorded and PISA values were calculated. Serum total antioxidant status (TAS), total oxidant status (TOS), and zinc levels were examined biochemically. Oxidative stress index (OSI) levels were calculated.
RESULTS
All clinical periodontal parameters, periodontal epithelium surface area, and PISA values were lower in the PH group than the P and G groups (p < 0.05). Serum zinc and TAS values were higher in the PH group than the P and G groups (p < 0.05). Serum TOS and OSI values were lower in the PH group than the G and P groups (p < 0.05). Serum OSI levels were lower in the G group than the P group (p < 0.05). PISA was associated with serum zinc (β = -28.96, 95% CI = (-38.95, -18.98), p < 0.001) and OSI (β = 89.84, 95% CI = (20.63, 159.05), p = 0.011) levels in the multivariate generalized linear model.
CONCLUSION
PISA values were associated with decreasing serum zinc and TAS and increased TOS and OSI levels. Zinc deficiency can be associated with the severity of periodontal disease and higher oxidative stress levels.
背景/目的：锌是某些酶的结构组成部分。本研究旨在评估血清锌与氧化应激水平和牙周炎炎症表面面积（PISA）之间的潜在关联。
材料和方法
本研究纳入了 90 名患者，分为三组：牙周炎组（P；n = 30）、牙龈炎组（G；n = 30）和牙周健康组（PH；n = 30）。记录牙周参数并计算 PISA 值。通过生化方法检测血清总抗氧化状态（TAS）、总氧化状态（TOS）和锌水平。计算氧化应激指数（OSI）水平。
结果
PH 组的所有临床牙周参数、牙周上皮表面面积和 PISA 值均低于 P 组和 G 组（p < 0.05）。PH 组的血清锌和 TAS 值高于 P 组和 G 组（p < 0.05）。PH 组的血清 TOS 和 OSI 值低于 G 组和 P 组（p < 0.05）。G 组的血清 OSI 值低于 P 组（p < 0.05）。多元广义线性模型中，PISA 与血清锌（β = -28.96，95%CI = (-38.95, -18.98)，p < 0.001）和 OSI（β = 89.84，95%CI = (20.63, 159.05)，p = 0.011）水平相关。
结论
PISA 值与血清锌和 TAS 降低以及 TOS 和 OSI 水平升高有关。锌缺乏可能与牙周病的严重程度和更高的氧化应激水平有关。
Zotero 插件